The Effects of Exercise on Indirect Markers of Gut Damage and Permeability: A Systematic Review and Meta-analysis.

Sports Medicine
Sarah ChantlerKevin Deighton

Abstract

Exercise appears to cause damage to the endothelial lining of the human gastrointestinal tract and elicit a significant increase in gut permeability. The aim of this review was to determine the effect of an acute bout of exercise on gut damage and permeability outcomes in healthy populations using a meta-analysis. PubMed, The Cochrane Library as well as MEDLINE, SPORTDiscus and CINHAL, via EBSCOhost were searched through February 2019. Studies were selected that evaluated urinary (ratio of disaccharide/monosaccharide excretion) or plasma markers [intestinal Fatty Acid Binding Protein (i-FABP)] of gut permeability and gut cell damage in response to a single bout of exercise. A total of 34 studies were included. A random-effects meta-analysis was performed, and showed a large and moderate effect size for markers of gut damage (i-FABP) (ES 0.81; 95% CI 0.63-0.98; n = 26; p < 0.001) and gut permeability (Disaccharide Sugar/Monosaccharide Sugar) (ES 0.70; 95% CI 0.29-1.11; n = 17; p < 0.001), respectively. Exercise performed in hot conditions (> 23 °C) further increased markers of gut damage compared with thermoneutral conditions [ES 1.06 (95% CI 0.88-1.23) vs. 0.66 (95% CI 0.43-0.89); p < 0.001]. Exercise duration did not have any ...Continue Reading

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Citations

Apr 4, 2021·Nutrients·Andreas Blesl, Vanessa Stadlbauer
May 5, 2021·European Journal of Sport Science·Jamie N PughSharon M Madigan
May 7, 2021·Journal of Applied Physiology·Michelle A KingLindsay B Baker
Jun 17, 2021·European Journal of Applied Physiology·Kyle A SmithMichael J Ormsbee

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Methods Mentioned

BETA
urine collection

Software Mentioned

Cochrane
Comprehensive Meta - analysis ( CMA )
DigitizeIt
Cochrane Collaboration

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