PMID: 8607473Mar 1, 1996Paper

The effects of exogenous prostaglandin E2 on root resorption in rats

American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics
D I BoekenoogenR I Howes

Abstract

This study evaluated the amount and depth of root resorption associated with varying concentrations and frequencies of injectable, exogenous prostaglandin E2 (PGE2) in conjunction with orthodontic tooth movement in rats. The sample consisted of 155 maxillary right and left first molars from 88, 8-week old, male Sprague-Dawley rats. The animals were divided into three control groups and two experimental groups. The control animals were divided into one nonappliance and two appliance groups. The experimental animals were divided into 2- and 4-week experimental time periods that were further subdivided based on single and weekly injection intervals of PGE2 and four different injectable concentration levels, i.e., 0.1, 1.0, 5.0, and 10.0 micrograms. A fixed orthodontic appliance was ligated between the maxillary incisors and maxillary first molars with closed-coil nickel-titanium springs. The appliance had an initial activating force of 60 gm. Serial histologic sections of the mesial root of the maxillary first molar were made, and a quantitative histomorphometric analysis of root resorption on the mesial and distal surfaces was performed. This study demonstrated increased root surface resorption when using exogenous PGE2 injection...Continue Reading

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Citations

Nov 9, 2005·Journal of Periodontology·Marc SchätzleDieter D Bosshardt
May 8, 2007·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·James R MillerPatricia M Vayda
Nov 27, 2010·Journal of Periodontal Research·E Crespo VázquezM A Rodriguez Cobos
Sep 19, 2006·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Oscar R Arias, Maria C Marquez-Orozco
Jun 6, 2008·Journal of Orthodontics·Mohsen ShiraziAhmad R Dehpour
Aug 20, 2015·Dental Research Journal·Hosseinagha AghiliMahdjoube Goldani Moghadam
Nov 20, 2002·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Ali Reza SekhavatFatemeh Sari Aslani
Sep 20, 2005·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Elias G Katsavrias, Demetrios J Halazonetis
Mar 15, 2003·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Riyad A Al-QawasmiW Eugene Roberts
Apr 21, 2005·Journal of Dental Research·D D Bosshardt

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