The effects of exogenous thyroxine (T4) or triiodothyronine (T3), in the presence and absence of potassium perchlorate, on the incidence of metamorphosis and on serum T4 and T3 concentrations in larval sea lampreys (Petromyzon marinus L.)

General and Comparative Endocrinology
Richard G Manzon, J H Youson

Abstract

Larval sea lampreys (Petromyzon marinus) measuring 100-119 mm in length were exposed to thyroxine (T4; 10 mg liter-1) or 3,5,3'-triiodothyronine (T3; 1 mg liter-1) in the presence and absence of the goitrogen potassium perchlorate (KClO4; 0.01%), for 4-24 weeks. Every 4 weeks, treated and untreated (control) groups of sea lampreys were examined for external signs of metamorphosis and serum was assayed for T4 and T3 concentrations. Precocious metamorphosis was observed following 8, 12, and 24 weeks of KClO4 treatment; however, metamorphosis was not observed in any control, or T4-, T3-, T4+KClO4-, and T3+KClO4-treated larvae. In addition, serum T4 and T3 concentrations were 62 and 72% lower in KClO4-treated individuals than in control animals, respectively. Treatment with exogenous thyroid hormones (TH), in the presence or absence of KClO4, resulted in serum T4 concentrations which were significantly greater (1.2- to 58-fold) than those of the controls in all sampling periods except one, but serum T3 concentrations were not significantly elevated in more than 50% of the cases. TH+KClO4 treatments produced serum T3 concentrations which were significantly greater than those of KClO4-treated animals and never less than those of cont...Continue Reading

References

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Citations

Apr 7, 2005·Environmental Health Perspectives·Helen M CraneJ Anne Brown
Dec 3, 2015·BMC Developmental Biology·Yu-Wen Chung-DavidsonWeiming Li
Jun 8, 2014·General and Comparative Endocrinology·Lori A ManzonRichard G Manzon
Nov 7, 2016·General and Comparative Endocrinology·Alison M GardellC Loren Buck
Oct 20, 2009·Nutrition and Health·Sebastiano Venturi, Mattia Venturi
Oct 22, 2008·Genesis : the Journal of Genetics and Development·Mathilde Paris, Vincent Laudet
Jul 10, 2014·Environmental Monitoring and Assessment·M R Sijimol, Mahesh Mohan
Apr 6, 2011·Environmental Toxicology and Chemistry·Richard R BernhardtTodd M O'Hara
Jun 12, 2001·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·J H Youson, S A Sower
Dec 13, 2005·The Journal of Experimental Biology·Andreas Heyland, Leonid L Moroz
May 21, 1999·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·Y KaoJ H Youson
Oct 24, 2002·General and Comparative Endocrinology·Richard G Manzon, John H Youson
Jan 16, 2007·General and Comparative Endocrinology·Richard G ManzonLori A Manzon
Dec 18, 2010·General and Comparative Endocrinology·Tianna Natalia Gross, Richard Giuseppe Manzon

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