The effects of exogenously administered testosterone on spermatogenesis in intact and hypophysectomized rats

Endocrinology
Y T SunD M de Kretser

Abstract

The effects of exogenously administered testosterone on the maintenance of spermatogenesis in intact and hypophysectomized rats were examined. Adult male rats were given Silastic implants containing testosterone in lengths ranging from 0.5-20 cm, and their effects on daily sperm production (DSP); serum FSH, LH, and testosterone; and interstitial fluid testosterone were determined in intact and hypophysectomized rats over a 13-week period. In intact rats, DSP levels were suppressed to 4-30% of control values at lower testosterone doses (2- to 6-cm implants), while DSP levels were partially maintained (65-93%) at higher doses (greater than or equal to 8 cm implants). Under these conditions LH levels were suppressed while FSH levels were reduced to 30-60% of control values. A steep testosterone-induced change in DSP levels was observed in both intact (2- to 3-fold) and hypophysectomized (18-fold) animals over a narrow testosterone dose range (implant lengths, 6-8 cm). Interstitial fluid testosterone levels associated with this change in DSP levels range from 6-8% of control values, while serum testosterone levels were elevated 1- to 2-fold above control values. A comparison of the testosterone implant lengths that caused a 50% cha...Continue Reading

Citations

Apr 1, 1995·Trends in Endocrinology and Metabolism : TEM·R I McLachlanD M de Kretser
Sep 16, 2000·Molecular and Cellular Endocrinology·J TesarikE Greco
Apr 1, 1992·Baillière's Clinical Endocrinology and Metabolism·D M de KretserN G Wreford
Nov 19, 2003·The Journal of Pain : Official Journal of the American Pain Society·Sachia G KhasarJon D Levine
Dec 24, 2005·Asian Journal of Andrology·Yinusa RajiAyodele Olufemi Morakinyo
Sep 7, 2004·The Journal of Pharmacology and Experimental Therapeutics·Jiyun ChenJames T Dalton
Jan 15, 2016·Current Opinion in Urology·Mohit Khera
Jan 1, 1991·Annals of the New York Academy of Sciences·K P Roberts, B R Zirkin
Sep 1, 2007·Environmental Toxicology and Pharmacology·Amar K ChandraMahitosh Sarkar
Jul 9, 2003·International Journal of Andrology·Robert Ochsenkühn, David M De Kretser
Jan 18, 2006·Biochemical and Biophysical Research Communications·Xiaomin MuChawnshang Chang
Mar 7, 2014·Seminars in Cell & Developmental Biology·Peter J O'Shaughnessy
Oct 12, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Osamu TakahashiAkio Ogata
Feb 6, 2015·Asian Journal of Andrology·Mohit Khera
May 4, 2012·Toxicologic Pathology·Robert E Chapin, Dianne M Creasy
Jan 1, 1991·Annals of the New York Academy of Sciences·M K SkinnerC T Anthony
Mar 7, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Olayiwola O OduwoleIlpo T Huhtaniemi
Jan 9, 2019·Frontiers in Endocrinology·Olayiwola O OduwoleIlpo T Huhtaniemi
Jun 5, 2018·Reproduction, Fertility, and Development·A KumarN H Balasinor
May 1, 2014·Spermatogenesis·Suresh Ramaswamy, Gerhard F Weinbauer
Feb 11, 2021·American Journal of Reproductive Immunology : AJRI·Emily R BryanAlison J Carey
May 1, 2021·Biology of Reproduction·Millissia Ben MaamarMichael K Skinner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.