The effects of exposure to pyriproxyfen and predation on Zika virus infection and transmission in Aedes aegypti

PLoS Neglected Tropical Diseases
Abdullah A AlomarBarry W Alto

Abstract

Zika virus (ZIKV) is an emerging mosquito-borne pathogen that can cause global public health threats. In the absence of effective antiviral medications, prevention measures rely largely on reducing the number of adult mosquito vectors by targeting juvenile stages. Despite the importance of juvenile mosquito control measures in reducing adult population size, a full understanding of the effects of these measures in determining mosquito phenotypic traits and in mosquito-arbovirus interactions is poorly understood. Pyriproxyfen is a juvenile hormone analog that primarily blocks adult emergence, but does not cause mortality in larvae. This mechanism has the potential to work in combination with other juvenile sources of mortality in nature such as predation to affect mosquito populations. Here, we experimentally evaluated the effects of juvenile exposure to pyriproxyfen and predatory mosquito Toxorhynchites rutilus on Aedes aegypti phenotypes including susceptibility to ZIKV infection and transmission. We discovered that combined effects of pyriproxyfen and Tx. rutilus led to higher inhibition of adult emergence in Ae. aegypti than observed in pyriproxyfen or Tx. rutilus treatments alone. Adult body size was larger in treatments co...Continue Reading

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Citations

Jul 3, 2021·Tropical Medicine and Infectious Disease·Youssef A Kousa, Reafa A Hossain

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Datasets Mentioned

BETA
KU501215

Methods Mentioned

BETA
dissection

Software Mentioned

IMT i - Solution
SAS

Related Concepts