The effects of extended training and acute administration of an anxiolytic on avoidance learning and intertrial responding in the Syracuse strains of rats

Behavior Genetics
C M Gendron, F R Brush

Abstract

Male and female animals of the SHA/Bru and SLA/Bru strains of rats were given extended two-way avoidance training in the shuttle box at the rate of 30 trials per day for 11 days. SLA/Bru animals increased their avoidance responses (AVRs) from approximately 10 to roughly 25%, whereas animals of the SHA/Bru strain remained unchanged at approximately 100% AVRs. SHA/Bru animals made a number of intertrial responses (ITRs) early in the experiment; these declined after about 3 days to the low level made by SLA/Bru animals. Chlordiazepoxide (CDP) had no effect on AVRs in animals of either strain, and had no effect on ITRs made by animals of the SHA/Bru strain, but increased ITRs, in a dose-dependent way, in animals of the SLA/Bru strain. These results are interpreted in terms of the well-established genetic difference in emotional reactivity between animals of the two strains and in terms of genetically determined differences in sensitivity to anxiolytic drugs such as CDP.

References

Mar 29, 1979·Psychopharmacology·S V Vellucci, S E File
Jul 1, 1979·Behavior Genetics·F R BrushP C Sakellaris
Apr 1, 1988·Behavioral Neuroscience·M S Fanselow, F J Helmstetter

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Citations

Oct 24, 1998·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·T SteimerP Driscoll
May 9, 2006·Hormones and Behavior·Magnus LöfgrenTorbjörn Bäckström
Jun 10, 2008·Biological Psychology·Mitzi GonzalesNancy K Dess

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