PMID: 7192855Nov 1, 1980Paper

The effects of extracellular potassium, ouabain, and prostaglandins on intracellular potassium activity in sheep cardica Purkinje fibers

Pflügers Archiv : European journal of physiology
M WiederholtK D Platsch

Abstract

(1) Intracellular K activity (aKi) of sheep heart Purkinje fibers was measured using K-selective microelectrodes (liquid ion exchanger). aKi in the resting state with an extracellular K of 4 mmol . l-1 EK was 112.9 +/- 6.1 mmol . l-1 (n = 47) for a membrane potential (VM) of -73.3 +/- 0.9 mV. VM deviated from the calculated potassium equilibrium potential (EK = -93mV). (2) When extracellular K was decreased to 2 mmol . l-1 or increased to 6 and 10 mmol . l-1 EK changed from -114 to -84 and -73 mV, with little change in aKi. (3) aKi and VM significantly decreased after administration of 10(-6) mol . l-1 ouabain. (4) Prostaglandins (PGI2 10-100 micrograms . l-1 and PGE2 0.01-1 microgram . l-1) decreased aKi without greatly changing VM. The differences between VM and EK became smaller. These effects indicate an increase in K permeability and may explain the antiarrhythmic action of prostaglandins.

References

Jan 1, 1979·The American Journal of Cardiology·L H OpieW F Lubbe
Sep 1, 1979·The American Journal of Physiology·C O Lee, H A Fozzard
Oct 1, 1979·Experimental Eye Research·L L HansenM Wiederholt
Mar 11, 1977·Pflügers Archiv : European journal of physiology·N FowlerG Whittembury
Jan 1, 1974·Reviews of Physiology, Biochemistry and Pharmacology·M P Blaustein
Jun 1, 1973·Prostaglandins·W FörsterP Mentz
May 1, 1972·European Journal of Pharmacology·W G ZijlstraA J Vergroesen

Citations

Dec 1, 1989·Pflügers Archiv : European journal of physiology·E KrohnH J Bretschneider
Mar 1, 1983·Prostaglandins, Leukotrienes, and Medicine·H J Mest, J Rausch
Sep 1, 1996·Japanese Circulation Journal·Y KobayashiT Katagiri

Related Concepts

Electric Stimulation Technique
Potentials, Event-Related
Cardiac Conduction System
Resting Potentials
Ouabain
Potassium
Prostaglandins
Structure of Purkinje Fibers
Dall Sheep

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