PMID: 2116311Jan 1, 1990Paper

The effects of felodipine in angina pectoris

European Journal of Clinical Pharmacology
A R LorimerT D Lawrie

Abstract

The clinical response to felodipine, in addition to a beta-blocker, was evaluated and compared with placebo in this double-blind cross-over study. Twenty patients with exertional angina pectoris completed the study. Felodipine reduced the number of angina attacks and the Glyceryl Trinitrate (GTN) consumption. The median exercise capacity was increased 33% after 4 weeks' felodipine treatment compared with placebo. At maximal exercise, systolic blood pressure and rate pressure product were reduced by felodipine while no change was seen in heart rate or ST-depression. Felodipine reduced both supine and erect blood pressure. The mean supine blood pressure at rest was 138/82 mm Hg after four weeks' placebo treatment compared with 114/71 mmHg after felodipine 5-10 mg b.i.d. Felodipine has overall a modest but significant anti-anginal benefit when combined with a beta-blocker.

References

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Citations

May 20, 1998·The American Journal of Cardiology·P H DunselmanP J Bernink
Aug 15, 1991·The American Journal of Cardiology·G SantoroC Giusti
Jul 24, 2001·Medical & Biological Engineering & Computing·K L ParkH R Yoon
Jun 30, 2009·Annals of Biomedical Engineering·Peter M van DamAdriaan van Oosterom

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