PMID: 9447851Feb 3, 1998Paper

The effects of fentanyl on sevoflurane requirements for loss of consciousness and skin incision

Anesthesiology
T Katoh, K Ikeda

Abstract

Fentanyl produces a minimal reduction in the minimum alveolar concentration of sevoflurane to prevent response to a verbal command in 50% of patients (MAC[awake]) at low but analgesic plasma concentrations. The reduction in MAC(awake), however, is still unknown at higher fentanyl concentrations. The reduction in the MAC of sevoflurane by fentanyl has not been described accurately. The purpose of this study was to determine the MAC(awake) and MAC reduction of sevoflurane by fentanyl. Ninety-two patients were randomly allocated to seven fentanyl concentration groups (target plasma concentrations of 0, 1, 1.5, 3, 6, 10, and 14 ng/ml). Responses to verbal command were observed for MAC(awake) assessment at predetermined sevoflurane concentrations. Thereafter, in patients whose target fentanyl concentration was 0 to 10 ng/ml, responses to skin incision were observed for MAC assessment at new steady-state sevoflurane concentrations. The reduction in the MAC(awake) and MAC of sevoflurane by the measured fentanyl concentration was calculated. There was an initial steep reduction in the MAC of sevoflurane by fentanyl, with 3 ng/ml resulting in a 59% MAC reduction. A ceiling effect was observed, with 10 ng/ml providing only a further 17% ...Continue Reading

References

Oct 14, 1977·European Journal of Clinical Pharmacology·M MichielsJ Heykants
Oct 1, 1992·Anesthesia and Analgesia·R J TelfordJ R Jacobs
Jan 1, 1992·Anesthesiology·P S SebelT Quill
Jul 1, 1989·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·W M Splinter, F Cervenko
Sep 1, 1987·Anesthesiology·I KissinE L Bradley
Aug 1, 1994·Anesthesia and Analgesia·Y InagakiI Yoshiya
Sep 1, 1994·British Journal of Anaesthesia·T KatohK Ikeda
Dec 1, 1993·Anesthesiology·J F Antognini, K Schwartz
May 1, 1993·Anesthesiology·A I McEwanP S Glass

❮ Previous
Next ❯

Citations

Oct 12, 2013·Journal of Clinical Monitoring and Computing·Umberto LucangeloWalter A Zin
Feb 22, 2014·Anesthesia and Analgesia·Chien-Kun TingDwayne R Westenskow
Dec 5, 2000·British Journal of Anaesthesia·F KerbaulJ P Auffray
Apr 18, 2006·Journal of Cardiothoracic and Vascular Anesthesia·François KerbaulFrédéric Collart
Apr 26, 2014·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Silvia Perez-ProttoDaniel I Sessler
Dec 11, 2013·Translational Stroke Research·Lana J MawhinneyMichael C Lewis
Apr 6, 2004·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Nathalie NathanPierre Feiss
May 29, 2007·Der Anaesthesist·S KreuerT Bouillon
Aug 17, 2001·International Anesthesiology Clinics·Y NakataS Morita
Dec 8, 2004·CNS Drugs·Richard Beers, Enrico Camporesi
May 1, 2002·Anesthesiology·James Sonner, Dennis M Fisher
May 25, 2002·Acta Anaesthesiologica Scandinavica·H AssarehJ Jakobsson
Dec 21, 2002·Acta Anaesthesiologica Scandinavica·C LentschenerY Ozier
Feb 9, 2000·Pharmacology & Therapeutics·N J O'Keeffe, T E Healy
Mar 20, 2009·European Journal of Anaesthesiology·Rakesh Garg
Jan 19, 2013·The Clinical Journal of Pain·Marilù GiacaloneFrancesco Forfori
Dec 18, 2015·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Robrecht De MedtsRik Carette
Nov 14, 2015·Anesthesiology·Sinziana AvramescuBeverley A Orser
Jun 23, 2009·Veterinary Anaesthesia and Analgesia·Mohammad Reza SeddighiThomas J Doherty
Jun 23, 2015·Anesthesia and Analgesia·William C Van CleveG Alec Rooke
Feb 1, 2005·European Journal of Anaesthesiology·E MeaudreB Palmier
Apr 26, 2011·Respiratory Physiology & Neurobiology·Luc J Teppema, Santhosh Baby
Nov 29, 2007·Anesthesiology·Satoshi HagihiraTakashi Mashimo
Jan 10, 2012·Anesthesiology·Bjorn HeyseMichel M R F Struys
May 11, 2016·European Journal of Anaesthesiology·Jan HendrickxAndre De Wolf

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.