The effects of FG 7142 upon local cerebral glucose utilization suggest overlap between limbic structures important in anxiety and convulsions

Brain Research
J A PrattJ McCulloch

Abstract

The effects of the beta-carboline benzodiazepine receptor ligand FG 7142 upon local cerebral glucose utilization have been examined in conscious rats using the quantitative [14C]2-deoxyglucose autoradiographic technique. FG 7142 (1-10 mg/kg i.v.) produced behavioural changes consistent with an anxiogenic action. At the largest dose of FG 7142 (10 mg/kg) 30% of the animals experienced overt convulsions. In the data analysis animals were divided according to the behavioural response elicited by the drug. In animals not expressing convulsions, FG 7142 (1-10 mg/kg) effected increases in glucose utilization in 33 of the 65 regions examined. The majority of changes were confined to limbic structures with pronounced effects occurring in the mammillary body, anterior thalamic nuclei, septal nuclei and the oriens and molecular layers of the hippocampus. Glucose use in other structures associated with auditory and visual processing, such as the medial and lateral geniculate body, and associated cortical areas, was also significantly increased. However, brain regions involved in motor control were minimally affected. The patterns of local cerebral glucose use in animals expressing FG 7142-induced convulsions were contrasted with those fro...Continue Reading

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Citations

Jan 1, 1992·Pharmacology & Therapeutics·J A Pratt
Mar 1, 1996·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·M JessaA Plaznik
Apr 20, 2001·Journal of Chemical Neuroanatomy·C W HarleyR J Blanchard
Jun 23, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Claire Allison, Judith A Pratt
Mar 4, 2008·Pharmacology, Biochemistry, and Behavior·Héctor González-PardoAndrés Parra
Mar 28, 2009·Journal of Neuroscience Research·Neil DawsonPaul A T Kelly
May 1, 1991·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·W Haefely

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