The effects of FK506 on neurologic and histopathologic outcome after transient spinal cord ischemia induced by aortic cross-clamping in rats

Anesthesia and Analgesia
L Lang-LazdunskiJ Mantz

Abstract

Spinal cord injury is a devastating complication of thoracoabdominal aortic surgery. We investigated the effect of the immunosuppressant FK506, a macrolide antibiotic demonstrated to have neuroprotective effects in cerebral ischemia models, in a rat model of transient spinal cord ischemia. Spinal cord ischemia was induced in anesthetized rats by using direct aortic arch plus left subclavian artery cross-clamping through a limited thoracotomy. Experimental groups were as follows: sham-operation; control, receiving only vehicle; FK506 A, receiving FK506 (1 mg/kg IV) before clamping; and FK506 B, receiving FK506 (1 mg/kg IV) at the onset of reperfusion. Neurologic status was assessed at 24 h and then daily up to 96 h with a 0 to 6 scale (0, normal function; 6, severe paraplegia). Rats were randomly killed at 24, 48, or 96 h, and spinal cords were harvested for histopathology. Physiologic variables did not differ significantly among experimental groups. All control rats suffered severe and definitive paraplegia. FK506-treated rats had significantly better neurologic outcome compared with control. Histopathologic analysis disclosed severe injury in the lumbar gray matter of all control rats, whereas most FK506-treated rats had less ...Continue Reading

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Citations

Aug 17, 2005·Proceedings of the National Academy of Sciences of the United States of America·Wei HuangCynthia L Grosskreutz
Dec 24, 2003·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Serdar AkgunAydin Sav
Dec 22, 2007·Pediatric Neurosurgery·Nejmi KiymazCetin Refik Kayaoğlu
Mar 18, 2020·Bulletin of Experimental Biology and Medicine·S S PashinM Yu Ivanova
Jan 20, 2021·Fundamental & Clinical Pharmacology·Khashayar AfshariAmir Hossein Abdolghaffari
Sep 18, 2021·Journal of Neuropathology and Experimental Neurology·Hamdy AwadEsmerina Tili
Oct 26, 2016·Journal of Vascular Surgery·Bao-Ngoc NguyenMichael T Watkins

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