The effects of flurbiprofen and indomethacin on the mitogenic response of human peripheral mononuclear cells

Immunopharmacology
A M Jawad, H J Rogers

Abstract

The effects of flurbiprofen (FBP) and indomethacin (INDO) on the incorporation of [3H]thymidine into human peripheral mononuclear cells after stimulation with phytohaemagglutinin (PHA), concanavalin A (Con A) and pokeweed mitogen (PWM) were investigated. FBP and INDO enhanced [3H]thymidine incorporation only at suboptimal concentrations of PHA and Con A but the concentration of PWM was less critical. Enhancement depended upon the presence of mononuclear cells which could be removed by adherence to plastic: these may be tentatively identified as monocytes (macrophages). INDO enhanced [3H]thymidine uptake to a greater degree than FBP and its effect was decreased to a greater extent by removal of monocytes. The enhancing effects of INDO and FBP are completely reversible by thorough washing of cells which had been exposed to the drugs and could be regained by direct addition of drugs to previously washed cells. Concurrent addition of both drugs to cell cultures showed neither antagonism nor synergy with respect to the effect of one drug alone. PGE2 inhibited [3H]thymidine incorporation. Like that of FBP and INDO, this action was dependent on mitogenic dose and apparent at suboptimal doses only. A low concentration of exogenous PGE2...Continue Reading

References

Jan 1, 1978·Scandinavian Journal of Immunology·U PerssonC I Smith
Jan 1, 1977·Current Medical Research and Opinion·S S AdamsD B Yates
Aug 1, 1979·The Journal of Clinical Investigation·J S Goodwin, R P Messner
Jun 1, 1976·Scandinavian Journal of Immunology·A Bøyum
Oct 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·M HambergB Samuelsson
Mar 1, 1971·American Journal of Clinical Pathology·L T YamW H Crosby
Apr 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·J L HumesF A Kuehl

❮ Previous
Next ❯

Citations

Dec 1, 1987·Cellular Immunology·Y IbayashiS H Golub

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.