The effects of gamma irradiation on the survival and development of Clonorchis sinensis metacercariae

Kisaengch'unghak chapchi. The Korean journal of parasitology
S H LeeJ Y Chai

Abstract

The effects of gamma irradiation on the survival and development of C. sinensis metacercariae were studied to evaluate the feasibility of irradiation as a control measure for clonorchiasis. Pseudorasbora parva were collected at an endemic river of clonorchiasis and were used for irradiation of the fluke in three schemes. The first (Scheme 1) was irradiation of the isolated metacercariae from the fish followed by infection to experimental rats. The second (Scheme 2) was irradiation of the fish, and then the metacercariae were isolated and infected to rats. The third (Scheme 3) was irradiation on the rat livers after infection with normal metacercariae. Irradiation doses varied from 5 to 100 Gy for Schemes 1 and 2, and 10 to 25 Gy for Scheme 3. The rats were sacrificed 2 to 6 weeks after infection. In Scheme 1, the metacercariae irradiated at 50 Gy failed to survive in the rats after 2 or 6 weeks. However, 1 to 44% of the metacercariae irradiated at 5-30 Gy survived. The estimated LD50 of Scheme 1 was 16.5 Gy. The flukes irradiated in Scheme 2 survived better than those in Scheme 1. The average worm recovery rate in 50 Gy was 28%(7-39% individually). Increasing the dose up to 100 Gy brought a remarkably low survival rate of an av...Continue Reading

Citations

Jan 29, 2008·Parasitology Research·Tae Im KimEun-Hee Shin
Sep 7, 2005·International Journal for Parasitology·Jong-Yil ChaiAlan J Lymbery
Sep 27, 2005·Memórias do Instituto Oswaldo Cruz·Fu Shi QuanHun Mo Yang
Jul 26, 2003·The Journal of Parasitology·J R Yu, W Y Park
Apr 2, 2003·The Korean Journal of Parasitology·Gab-Man Park, Tai-Soon Yong
Nov 4, 2009·The Korean Journal of Parasitology·Tae Im KimSung-Jong Hong
Jun 1, 1993·The Korean Journal of Parasitology·W M SohnS H Lee

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