The effects of genes implicated in cardiovascular disease on blood pressure response to treatment among treatment-naive hypertensive African Americans in the GenHAT study

Journal of Human Hypertension
A N DoMarguerite R Irvin

Abstract

African Americans have the highest prevalence of hypertension in the United States. Blood pressure (BP) control is important to reduce cardiovascular disease-related morbidity and mortality in this ethnic group. Genetic variants have been found to be associated with BP response to treatment. Previous pharmacogenetic studies of BP response to treatment in African Americans suffer limitations of small sample size as well as a limited number of candidate genes, and often focused on one antihypertensive treatment. Using 1131 African-American treatment-naive participants from the Genetics of Hypertension Associated Treatment Study, we examined whether variants in 35 candidate genes might modulate BP response to four different antihypertensive medications, including an angiotensin-converting enzyme inhibitor (lisinopril), a calcium channel blocker (amlodipine), and an a-adrenergic blocker (doxazosin) as compared with a thiazide diuretic (chlorthalidone) after 6 months of follow-up. Several suggestive gene by treatment interactions were identified. For example, among participants with two minor alleles of renin rs6681776, diastolic BP response was much improved on doxazosin compared with chlorthalidone (on average -9.49 mm Hg vs -1.70...Continue Reading

References

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Citations

Jun 12, 2018·Expert Review of Precision Medicine and Drug Development·Michael T EadonArlene B Chapman
Jan 15, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·John SiemonMatthew Schlumbrecht
Apr 10, 2019·Current Clinical Pharmacology·Ewoud-Jan van HoogdalemMeguru Achira

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Methods Mentioned

BETA
PCR

Software Mentioned

SAS
GenHAT
ALLHAT

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