PMID: 3754212Jan 1, 1986Paper

The effects of genkwadaphnin and gnidilatidin on the growth of P-388, L-1210 leukemia and KB carcinoma cells in vitro

European Journal of Cancer & Clinical Oncology
I H HallK H Lee

Abstract

Daphnane diterpene esters have previously been shown to have antineoplastic activity in vivo against the growth of P-388 lymphocytic leukemia cells. These studies demonstrate cytotoxic activity of genkwadaphnin and gnidilatidin against P-388 lymphocytic leukemia, L-1210 lymphoid leukemia and human KB carcinoma cell growth in vitro. At the ED50 values in the respective tumor lines DNA synthesis was preferentially suppressed in all three cell lines. RNA synthesis was essentially unaffected by the agents. Protein synthesis inhibition by the two agents demonstrated selectivity, e.g. in P-388 cells significant inhibition, in L-1210 cells marginal inhibition and in KB cells no inhibition was observed at these concentrations. Multiple sites in DNA synthesis were found to be inhibited by the daphnane diterpene esters. Two to three times the ED50 concentration in the respective tumor lines was required to observe suppression of DNA synthesis. Purine de novo synthesis appeared to be the major site of inhibition, with inosine monophosphate dehydrogenase and phosphoribosyl pyrophosphate amido transferase activities being inhibited in all three tissue lines. Dihydrofolate reductase activity was inhibited, significant only in the P-388 and K...Continue Reading

References

Apr 1, 1977·Journal of Medicinal Chemistry·B F Cain, W A Denny
Oct 15, 1979·Klinische Wochenschrift·H J Becher, G W Löhr
Nov 26, 1976·The Journal of Organic Chemistry·S M KupchanB R Sickles
Feb 21, 1975·Science·S M Kupchan, R L Baxter
Feb 5, 1975·Journal of the American Chemical Society·S M KupchanB R Sickles
Apr 15, 1976·Biochemical Pharmacology·M K SpassovaE V Golovinsky

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Citations

Jun 2, 2009·Chemical Reviews·Lizbeth Hedstrom
Jun 23, 2015·Journal of Cellular Biochemistry·Ho-Bum KangJae Wha Kim
Aug 9, 2005·The International Journal of Biochemistry & Cell Biology·Mohammad Amin MoosaviAbdolfattah Sarraf Nejad
Aug 2, 2005·Journal of Biochemistry and Molecular Biology·Mohammad Amin MoosaviMohammad Hasan Sanati
May 29, 2014·Journal of Women's Health·Memoona HasnainLaura Szalacha
Mar 13, 2009·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·S X ZhangY M Sun
Feb 3, 2009·Chemical Reviews·Shang-Gao LiaoJian-Min Yue

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