The effects of gestational diabetes mellitus on fetal growth and neonatal birth measures in an African cohort

Diabetic Medicine : a Journal of the British Diabetic Association
S MacaulayS A Norris

Abstract

Fetal exposure to gestational diabetes mellitus (GDM) is said to alter fetal growth and increase the risk of macrosomia. However, little research on GDM exists in African populations. This study aimed to assess longitudinal fetal growth and neonatal birth measures among Black African babies exposed to GDM. Pregnant women (Soweto, South Africa) enrolled into a cohort study were followed up with repeated fetal ultrasounds. At 24-28 weeks' gestation a 2-h 75 g oral glucose tolerance test was performed and GDM was diagnosed using the World Health Organization's 2013 criteria. Neonatal birth measures were assessed. The study involved 741 women; 83 (11.2%) with GDM and 658 (88.8%) without. A total of 4040 fetal ultrasounds were performed. GDM exposure was associated with an increase in fetal growth measures, especially abdominal circumference, which was already seen at 16-18 weeks' gestation. Male fetuses in particular, showed a significant association between GDM exposure and increased abdominal circumference (P = 0.009). Most women with GDM (66.3%) received management; all received diet therapy and 32.7% were prescribed medication. There was no difference in birth measures between the GDM-exposed and unexposed neonates. Repeated ul...Continue Reading

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Citations

Feb 18, 2020·Journal of Developmental Origins of Health and Disease·Alessandra PrioreschiShane A Norris
May 1, 2020·Paediatric and Perinatal Epidemiology·Rodrigo A LimaMireille van Poppel
Oct 1, 2020·Pediatric Obesity·Stephanie V WrottesleyShane A Norris
Nov 30, 2019·Maternal & Child Nutrition·Stephanie V WrottesleyShane A Norris
Dec 1, 2018·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Charlotte Pauline Joëlle Talbot, Vernon Wayne Dolinsky
May 13, 2020·Biology of Sex Differences·Zoe A Broere-BrownSarah Schalekamp-Timmermans
Aug 14, 2020·Revista brasileira de enfermagem·Diane Bressan PedriniMárcia Koja Breigeiron
Jan 30, 2021·Revista brasileira de ginecologia e obstetrícia : revista da Federação Brasileira das Sociedades de Ginecologia e Obstetrícia·Marcus Vinícius Rodrigues de SouzaKamilla Maria Araújo Brandão Rajão
Jul 20, 2021·Current Opinion in Pharmacology·Maria MirabelliAntonio Brunetti
Sep 26, 2021·BMC Pregnancy and Childbirth·Mohammad A A BayoumiRavi Agarwal

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