The effects of ginger supplementation on markers of inflammatory and oxidative stress: A systematic review and meta-analysis of clinical trials

Phytotherapy Research : PTR
Mohammad JalaliZahra Mosallanezhad

Abstract

The present systematic review and meta-analysis was conducted to investigate the effects of ginger supplementation on markers of inflammatory and oxidative stress. PubMed, Embase, Scopus, and Web of Science were systematically searched to identify relevant clinical trials evaluating the effects of ginger on serum CRP (C-reactive protein), TNF-α (tumor necrosis factor-alpha), IL-6 (interleukin-6), PGE2 (prostaglandin E2), TAC (total antioxidant capacity), and MDA (malondialdehyde) from inception up to September 2019. Mean difference and 95% confidence intervals were pooled using a random-effects model. Potential publication bias was assessed using visual inspection of funnel plot and Egger's weighted regression tests. After excluding irrelevant records, 20 full-text articles that included 25 separate studies were included to the meta-analysis. Pooled results of this study indicated a statistically significant effect of ginger on serum CRP, TNF-α, IL-6, TAC, and MDA levels following ginger supplementation in compared to the controls. Also, the effects of ginger on serum PGE2 was marginally significant. Moreover, the high heterogeneity was disappeared in subgroup analysis performed by age, duration, dosage, and quality. This curre...Continue Reading

References

Dec 7, 2002·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M ThomsonM Ali
Mar 8, 2005·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Phong V PhanCarmelita G Frondoza
Aug 11, 2006·Arthritis Research & Therapy·Cem Gabay
Oct 24, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Badreldin H AliAbderrahim Nemmar
Sep 9, 2008·Trends in Molecular Medicine·Hedi HariziNorbert Gualde
Mar 23, 2010·Cell·Sergei I GrivennikovMichael Karin
Apr 27, 2010·The Journal of Pain : Official Journal of the American Pain Society·Christopher D BlackPatrick J O'Connor
Jan 20, 2011·World Journal of Gastroenterology : WJG·Amirhossein Sahebkar
Sep 21, 2011·Critical Reviews in Food Science and Nutrition·Manjeshwar Shrinath BaligaSandhya Popuri
May 29, 2012·Current Pharmaceutical Design·Di Paola Rosanna, Cuzzocrea Salvatore
Aug 14, 2012·Journal of Critical Care·Zahra Vahdat ShariatpanahiShaahin Shahbazi
Feb 5, 2014·International Journal of Food Sciences and Nutrition·Tahereh ArablouMahmoud Djalali
Feb 27, 2015·Journal of Complementary & Integrative Medicine·Farzad ShidfarShahrzad Shidfar
Apr 1, 2015·Antioxidants & Redox Signaling·Daniele PastoriPasquale Pignatelli
Sep 12, 2015·International Journal of Evidence-based Healthcare·Catalin TufanaruEdoardo Aromataris
Apr 19, 2016·Journal of Complementary & Integrative Medicine·Rashmi Anant Kulkarni, Ajit Ramesh Deshpande
Aug 5, 2016·Molecular Nutrition & Food Research·Julia LuettigJörg D Schulzke
Aug 26, 2016·Journal of Nutrition in Gerontology and Geriatrics·Hassan Mozaffari-KhosraviHassan Fallah Huseini
May 16, 2017·Annals of the New York Academy of Sciences·Jing WangFang Chen
May 8, 2018·Clinical Interventions in Aging·Ilaria LiguoriPasquale Abete
Jul 4, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Amir M Al HroobAyman M Mahmoud
Aug 15, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Kristien DaenenBert Bammens
Mar 31, 2019·International Immunology·Kyoshiro TsugeYukihiko Sugimoto
Jun 27, 2019·Seminars in Immunopathology·Marc Y Donath

❮ Previous
Next ❯

Citations

Aug 3, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Jingxian YanZhimin Yan
Aug 14, 2021·BioFactors·Nazanin Momeni RoudsariAmirhossein Sahebkar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Oncology Nurse Edition
Julie L Ryan, Gary R Morrow
American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
K L Grant, R B Lutz
Midwives
Denise Tiran
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
D J YeR Guo
Zhong xi yi jie he za zhi = Chinese journal of modern developments in traditional medicine
H Q Meng
© 2021 Meta ULC. All rights reserved