The effects of glucose, mannose, fructose and lactate on the preservation of neural activity in the hippocampal slices from the guinea pig

Brain Research
H WadaH Nakamura

Abstract

Using hippocampal slices from guinea pigs, we investigated the effect of different concentrations of glucose and replacement of glucose with mannose, fructose and lactate on neural activity. As an index of neural activity, the population spikes (PS) were recorded in the granule cell layer of the dentate gyrus (DG) and the pyramidal cell layer of the CA3 area in the hippocampal slices. Lowering the concentration of glucose from 10 mM to 5, 3, 2, 1 and 0 mM caused a reduction in the PS amplitude. There were differences in the decay times of the PS evoked in these two regions. PS evoked in CA3 region decayed faster even at a concentration of 3 mM glucose at which PS in granule cell layer was well maintained. The decay time of the PS in the CA3 region in the presence of glucose up to a concentration of 3 mM was shorter than that evoked in the DG. After the replacement of glucose with mannose, fructose or lactate, the PS disappeared within 35 min and there were no significant differences between the decay times in the two regions of slices incubated in the same medium. ATP, creatine phosphate (CrP) and lactate levels in each slice were determined. To investigate whether mannose and fructose could be metabolized or not in the tissue ...Continue Reading

References

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Citations

Aug 13, 2011·Journal of Bioenergetics and Biomembranes·Maynara FornazariHenning Ulrich
Jun 26, 2013·Brain Research·Rashika N Karunasinghe, Janusz Lipski
Feb 26, 2004·Experimental Neurology·Zhongmin XiangPeter J Bergold
Nov 26, 2002·Journal of Physiology, Paris·Anne-Karine Bouzier-SoreLuc Pellerin
Oct 27, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Luc Pellerin, Pierre J Magistretti
May 4, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Paul J MeakinAngus M Brown
Jul 27, 2007·Brain Research·Matthew P SadgroveDennis A Turner
Apr 27, 2007·Neurobiology of Disease·Peter A AbdelmalikPeter L Carlen
Sep 3, 2005·Brain Research. Brain Research Protocols·Erin Gilbert, Peter J Bergold
Nov 26, 2009·Developmental Psychobiology·Jacqueline Fagard, Jeffrey J Lockman
Mar 25, 2017·Journal of Pediatric Rehabilitation Medicine·Brian Hoare, Susan Greaves
Mar 28, 2017·Neurochemical Research·Wiebke RastedtRalf Dringen
May 31, 2006·Neurochemical Research·Alexandre P MullerMarcos L S Perry
Dec 31, 2020·Nutrients·Maria Stefania SpagnuoloLuisa Cigliano

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