The effects of glucose or lipid infused intravenously or intragastrically on voluntary food intake in the rat

Physiology & Behavior
K K BurggrafH S Koopmans

Abstract

Glucose or lipid was infused intravenously (IV) or intragastrically (IG) 30 min before and also during the 17 h when rats were fed both a high-carbohydrate diet and a high-fat diet. Three-day infusions of 28.1 kcal of glucose reduced daily food intake by 19.7 +/- 1.9 kcal/day, representing an oral intake reduction equivalent to 70% of each calorie infused. Infusions of 28.1 kcal of lipid reduced baseline food intake by 11.2 +/- 2.7 kcal/day or 40% of each calorie infused (p < 0.0005). Furthermore, infusions of nutrient IG reduced baseline food intake by 17.6 +/- 2.1 kcal/day or 63% of each calorie infused, and infusions of nutrient IV reduced baseline food intake by 13.7 +/- 2.6 kcal/day or 49% of each calorie infused (p < 0.05). Also, glucose infusions (1.0 kcal/40 min) reduced 10-min food intake from saline baseline levels by 1.1 +/- 0.5 kcal, but lipid infusions had no effect. Infused glucose is more effective than lipid in inhibiting short-term intake, daily food intake, and intake of high-carbohydrate diet, and IG infusion is more effective than IV infusion in inhibiting daily food intake.

References

Jun 1, 1989·Physiology & Behavior·E K Walls, H S Koopmans
Sep 1, 1989·Physiology & Behavior·F Lucas, A Sclafani

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Citations

Sep 27, 2007·Physiological Genomics·Hong Ji, Alexander A Bachmanov
Jul 3, 2009·The American Journal of Clinical Nutrition·Alexander A BachmanovGary K Beauchamp
Jul 17, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Andrea L TracyT L Davidson
Feb 7, 2007·American Journal of Physiology. Endocrinology and Metabolism·G-Q ChangS F Leibowitz
Dec 15, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Wolfgang LanghansMyrtha Arnold
Jan 25, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Z S WarwickS J Synowski
Oct 29, 1998·The American Journal of Physiology·F LucasA Sclafani

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