The effects of glutamate and citrate on absorption and distribution of aluminum in rats

Biological Trace Element Research
Xin WuZe-yuan Deng

Abstract

The objective of this study was to evaluate the effect of glutamate (Glu) and citrate (Cit) on the absorption and distribution of aluminum in rats. In the in vitro experiment, 18 adult male Sprague-Dawley rats (average weight of 250 ± 15 g) were randomly divided into three groups. The entire intestine was rapidly removed and cultured in prediction samples of 20 mmol AlCl(3), 20 mmol AlCl(3)+20 mmol Cit, and 20 mmol AlCl(3)+20 mmol Glu, respectively. Liquid in different intestines and the intestines were obtained for Al determination. In the in vivo chronic study, 24 adult male Sprague-Dawley rats (average weight of 127 ± 10 g) were divided into four groups fed with the following diets: no Al and Glu added (control), AlCl(3) (1.2 mmol), AlCl(3) (1.2 mmol) + Cit (1.2 mmol), and AlCl(3) (1.2 mmol) + Glu (1.2 mmol) daily for 50 days, respectively. After rat sacrifice, blood samples were obtained for biochemical analyses, and organ samples like the brain, kidney, liver, and bone were rapidly taken for Al determination. The results showed that the absorption rate of Al with the following order: duodenum > jejunum > ileum in the in vitro study and the administration of AlCl(3)+Cit or AlCl(3)+Glu resulted in significant increases in Al...Continue Reading

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Citations

May 6, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Celeste Di PaoloMercedes Gómez
Dec 4, 2016·Annual Review of Animal Biosciences·Bie Tan, Yulong Yin
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Sep 2, 2020·Critical Reviews in Toxicology·Robert A Yokel
Dec 3, 2016·Biological Trace Element Research·Maria L Reina de la TorreMiguel Navarro-Alarcón
May 7, 2014·Journal of Agricultural and Food Chemistry·Yesudoss Christu RajanBing Huei Chen

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