Abstract
Reduced N-methyl-D-aspartate receptor (NMDAR) function may contribute to the pathogenesis of schizophrenia. Sarcosine, a potent glycine transporter inhibitor, can increase synaptic glycine and then promote NMDAR function. We assessed the antipsychotic potential of sarcosine by comparing the abilities of sarcosine and clozapine to restore the prepulse inhibition (PPI) deficit, hyperlocomotion and regional brain c-Fos expression changes caused by an NMDAR antagonist, ketamine. Four groups of rats were given acute injections, including saline+saline, saline+30 mg/kg ketamine, 100mg/kg sarcosine+30 mg/kg ketamine, and 15 mg/kg clozapine+30 mg/kg ketamine. Both sarcosine and clozapine reversed the ketamine-induced PPI deficit and hyperlocomotion. They both did not change ketamine-induced increase in c-Fos expression in the prefrontal cortex and nucleus accumbens. However, in the olfactory bulb, sarcosine, but not clozapine, significantly reduced the ketamine-induced increase in c-Fos expression. Our animal study demonstrated that sarcosine may have antipsychotic potential.
References
Feb 5, 1987·Nature·J W Johnson, P Ascher
Dec 1, 1989·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·R S Mansbach, M A Geyer
Aug 1, 1994·The American Journal of Psychiatry·D C JavittJ P Lindenmayer
Jan 1, 1993·Annual Review of Neuroscience·S G Amara, M J Kuhar
Mar 1, 1994·Archives of General Psychiatry·J H KrystalD S Charney
Jun 5, 1998·Schizophrenia Bulletin·N R Swerdlow, M A Geyer
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·R BergeronR W Greene
Jan 19, 1999·Archives of General Psychiatry·D C GoffJ T Coyle
Apr 28, 2000·The American Journal of Psychiatry·B I TuretskyR E Gur
Apr 2, 2003·The American Journal of Psychiatry·Bruce I TuretskyRaquel E Gur
May 29, 2003·Current Drug Targets. CNS and Neurological Disorders·M J Millan
Jul 15, 2003·Current Psychiatry Reports·Paul J Moberg, Bruce I Turetsky
Feb 5, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·David FeifelPaul D Shilling
Mar 17, 2004·Biological Psychiatry·Guochuan TsaiNicholas Lange
May 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Guochuan TsaiJoseph T Coyle
Dec 14, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Axel Becker, Gisela Grecksch
Jun 15, 2006·Cellular and Molecular Neurobiology·Joseph T Coyle
Jun 20, 2006·Biological Psychiatry·Hsien-Yuan LaneGuochuan Tsai
Jul 31, 2007·Biological Psychiatry·Hsien-Yuan LaneGuochuan E Tsai
Aug 22, 2009·Neuroscience and Biobehavioral Reviews·Viviane Labrie, John C Roder
Citations
Mar 11, 2010·Psychopharmacology·Hwei-Hsien ChenAthina Markou
Mar 23, 2011·Neuropsychobiology·Tomáš PáleníčekVladimír Krajča
Dec 4, 2015·Biological & Pharmaceutical Bulletin·Jianghao ZhaoBin Zhao
Nov 13, 2012·Neurobiology of Disease·Akihiro MouriKiyofumi Yamada
Oct 17, 2012·Toxicology and Applied Pharmacology·Ming-Huan ChanHwei-Hsien Chen
May 3, 2011·Neuropharmacology·Agnieszka NikiforukPiotr Popik
Feb 22, 2011·Biochemical Pharmacology·Hanns MöhlerBenjamin K Yee
Jul 22, 2010·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Philipp SingerBenjamin K Yee
Jan 24, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Ching-Ping YangYi-Ming Arthur Chen
Mar 6, 2012·European Journal of Pharmacology·Andrea de BartolomeisFelice Iasevoli
Jun 15, 2016·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jen-Cheng LinHwei-Hsien Chen
Jul 2, 2016·Psychopharmacology·Jen-Cheng LinHwei-Hsien Chen
Oct 20, 2017·Behavioural Pharmacology·Eric A MaltbieLeonard L Howell
Feb 4, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·S A CastnerM Laruelle
Feb 5, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Neil DawsonJudith A Pratt
Nov 1, 2013·Nature Reviews. Drug Discovery·Robert J Harvey, Benjamin K Yee
Jul 12, 2019·Current Medicinal Chemistry·Agnieszka JankowskaGrażyna Chłoń-Rzepa
Mar 16, 2019·Frontiers in Psychiatry·Chieh-Hsin Lin, Hsien-Yuan Lane
Jul 12, 2019·Journal of Psychopharmacology·Ju-Chun PeiWen-Sung Lai
Jun 2, 2020·Frontiers in Psychiatry·Andrea de BartolomeisAnnarita Barone
Sep 15, 2010·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Kazuhiro NakatoShoji Takakura