The effects of gonadotropin-releasing hormone agonist (buserelin) and orchidectomy on bone turnover markers and histomorphometry in rats.

The Aging Male : the Official Journal of the International Society for the Study of the Aging Male
Nur-Vaizura MohamadKok-Yong Chin

Abstract

This study aimed to compare the skeletal effect between GnRH agonist therapy and orchidectomy in male rats assessed using serum turnover markers and bone histomorphometry. Three-month-old male Sprague-Dawley rats (n = 46) were divided into three experimental arms, baseline, buserelin, and orchidectomy. In the buserelin arm, the rats received a daily subcutaneous injection of either normal saline or buserelin acetate at 25 µg/kg or 75 µg/kg. In the orchidectomy arm, the rats were either sham-operated or orchidectomized. The rats were euthanized after the three-month treatment. Blood was collected for the evaluation of bone turnover markers. Femurs were harvested for bone histomorphometry examination. A significant increase in serum C-telopeptide of type 1 collagen was observed in the orchidectomized group compared with the sham group (p < .05). Structural histomorphometry analysis showed that both buserelin (25 µg/kg and 75 µg/kg) and orchidectomy significantly decreased the trabecular bone volume, number and significantly increased trabecular separation in rats compared with their respective controls (p < .05). Osteoclast number and eroded surface were significantly increased in both buserelin (25 µg/kg and 75 µg/kg) and orchid...Continue Reading

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Aug 15, 2014·Clinical Interventions in Aging·Kok-Yong Chin, Soelaiman Ima-Nirwana
Aug 29, 2014·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Kok-Yong Chin, Soelaiman Ima-Nirwana
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Mar 8, 2018·International Journal of Medical Sciences·Nur-Vaizura MohamadKok-Yong Chin

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Citations

Jan 18, 2019·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Jianzhong ZhangBin Yang
Feb 12, 2019·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Naci BabatHalit Demir
Oct 26, 2018·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·M F DuarteJ M La Fuente

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