The effects of graded doses of a cholecystokinin-like peptide with and without secretin on pancreatic growth and synthesis of RNA and polyamines in rats.

Scandinavian Journal of Gastroenterology
H Haarstad, H Petersen

Abstract

The dose dependence of a cholecystokinin-like peptide (CCK-LP) on the trophic response in the rat pancreas was studied. Graded doses of Thr28Nle31CCK25-33 (0.02, 0.1, 0.5, 2.5, and 12.5 micrograms/kg/h) or saline were given as a continuous intravenous infusion to conscious and fed rats for 8 and 48 h. Secretin (5.0 micrograms/h) was given alone or combined with the three highest doses of CCK-LP for 48 h. CCK-LP showed a dose-dependent stimulating effect on pancreatic growth and synthesis of RNA and polyamines. The threshold dose ranged from 0.02 to 0.5 micrograms/kg/h and was lowest for stimulation of ornithine decarboxylase (ODC). The maximal effects on protein, RNA, and DNA contents were achieved with 2.5 micrograms/kg/h. These same variables markedly decreased with 12.5 micrograms/kg/h, whereas marked further increases were found for the activities of RNA polymerase, DNA polymerase, and thymidine kinase. This same dose of CCK-LP caused after 8 h of treatment a marked and transient increase in pancreatic weight, activity of ODC, and concentration of putrescine. When secretin was added to 0.5 and 2.5 micrograms/kg/h of CCK-LP, no additional effect (except for ODC) was found. When secretin was added to the highest dose of CCK-L...Continue Reading

References

Mar 11, 1977·Virchows Archiv. A, Pathological Anatomy and Histology·M Lampel, H F Kern
Jan 1, 1978·Scandinavian Journal of Gastroenterology·U R FölschK G Wormsley
May 1, 1985·Scandinavian Journal of Gastroenterology·H HaarstadH Petersen
May 1, 1986·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·I G Renner, J R Wisner
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Jul 1, 1967·The American Journal of Physiology·S S Rothman, H Wells
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Jan 1, 1980·Endocrinology·A B Dembinski, L R Johnson

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Citations

Feb 17, 2001·Regulatory Peptides·L M TrulssonT Gasslander
Jul 1, 1992·Scandinavian Journal of Gastroenterology·T GasslanderS Smeds
May 1, 1991·Molecular and Cellular Endocrinology·G ScalabrinoM E Ferioli

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