PMID: 36420Jun 1, 1979

The effects of H1 and H2 receptor antagonism on the response of monkey skin to intradermal histamine, reverse-type anaphylaxis, and passive cutaneous anaphylaxis

The Journal of Allergy and Clinical Immunology
B J HutchcroftR P Orange


The effects of H1 and H2 receptor anatagonists on models of allergic reactions in monkey skin have been studied. Intradermal histamine is markedly inhibited by H1 receptor antagonists but not by H2 receptor antagonists in the doses used. However, the combination of both receptor antagonists gives greater inhibition than that seen with H1 receptor blockade alone. Reverse-type anaphylaxis is also markedly inhibited by H1 but not H2 receptor antagonists. Passive cutaneous anaphylaxis (PCA) is likewise inhibited by H1 receptor antagonism, but not by H2 receptor antagonism. The combination of the two inhibitors leads to a complete inhibition of this PCA response. The data suggest that the addition of an H2 receptor antagonist may potentiate the effect of H1 blockade alone.


Dec 1, 1982·Inflammation·C LundbergB Björkstén
Sep 1, 1983·The Journal of Allergy and Clinical Immunology·T AhmedL D Yerger
Nov 1, 1982·The Journal of Allergy and Clinical Immunology·C D BrooksC Metzler
Mar 1, 1986·Journal of Veterinary Pharmacology and Therapeutics·A MorrowK P Baker
Dec 1, 1980·Clinical and Experimental Dermatology·M W Greaves

Related Concepts

Histamine Measurement
Receptors, Histamine H1
Histamine H2 Receptors
Anaphylaxis (Non Medication)
Passive Cutaneous Anaphylaxis
Histamine H2 Receptor Antagonists [MoA]
Dose-Response Relationship, Immunologic
Antihistamines, Classical

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