The effects of H2S on the activities of CYP2B6, CYP2D6, CYP3A4, CYP2C19 and CYP2C9 in vivo in rat

International Journal of Molecular Sciences
Xian-Qin WangG Y Lin

Abstract

Hydrogen sulfide (H2S) is a colorless, flammable, extremely hazardous gas with a "rotten egg" smell. The human body produces small amounts of H2S and uses it as a signaling molecule. The cocktail method was used to evaluate the influence of H2S on the activities of CYP450 in rats, which were reflected by the changes of pharmacokinetic parameters of five specific probe drugs: bupropion, metroprolol, midazolam, omeprazole and tolbutamide, respectively. The rats were randomly divided into two groups, control group and H2S group. The H2S group rats were given 5 mg/kg NaHS by oral administration once a day for seven days. The mixture of five probes was given to rats through oral administration and the blood samples were obtained at a series of time-points through the caudal vein. The concentrations of probe drugs in rat plasma were measured by LC-MS. In comparing the H2S group with the control group, there was a statistically pharmacokinetics difference for midazolam and tolbutamide; the area under the plasma concentration-time curve (AUC) was decreased for midazolam (p < 0.05) and increased for tolbutamide (p < 0.05); while there was no statistical pharmacokinetics difference for bupropion, metroprolol and omeprazole. H2S could not...Continue Reading

References

Jan 1, 1992·Annual Review of Pharmacology and Toxicology·R J ReiffensteinS H Roth
Oct 24, 2002·Molecular Neurobiology·Hideo Kimura
Nov 1, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rui Wang
Jun 20, 2003·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Kaoru KobayashiKan Chiba
Jun 29, 2004·Amino Acids·P Kamoun
Oct 24, 2007·Proceedings of the National Academy of Sciences of the United States of America·Gloria A BenavidesDavid W Kraus
Nov 10, 2007·Proceedings of the National Academy of Sciences of the United States of America·David J Lefer
Oct 23, 2009·Antioxidants & Redox Signaling·Rui Wang
Dec 17, 2009·British Journal of Clinical Pharmacology·Sandrine TurpaultXavier Boulenc
Mar 1, 2006·Biochemistry and Molecular Biology Education : a Bimonthly Publication of the International Union of Biochemistry and Molecular Biology·Laura Lowe Furge, F Peter Guengerich
Apr 10, 2012·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Kyung-Suk OhDong-Hyun Kim

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Citations

Feb 6, 2017·American Journal of Physiology. Cell Physiology·Nancy L KanagyAndreas Papapetropoulos
Jan 25, 2019·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Fengling WangWeidong Chen

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