The effects of Haemophilus influenzae vaccination on anaphylactic mediator release and isoprenaline-induced inhibition of mediator release

European Journal of Pharmacology
A J SchreursF P Nijkamp


The influence of Haemophilus influenzae on anaphylactic mediator release from ovalbumin-sensitized isolated guinea pig lungs was investigated. Lungs from H. influenzae-vaccinated animals released prostaglandins and thromboxanes following a smaller dose of ovalbumin than was effective in non-vaccinated animals. Histamine release was significantly increased in 4 day-vaccinated animals but not 1 or 10 days after vaccination, while broncho-constriction was potentiated in 1 and in 4 day-vaccinated animals. This increased histamine release was achieved following 2 micrograms ovalbumin. In contrast, doses of 10 micrograms and 1 mg ovalbumin respectively did not affect and decreased histamine release in the vaccinated group. The inhibition of anaphylactic mediator release by an infusion of 6 x 10(-9) M isoprenaline was significantly attenuated by H. influenzae vaccination. These results indicate an increased sensitivity to antigenic challenge and suggest that the functioning of beta-adrenoceptors was decreased as a result of H. influenzae vaccination.


Dec 1, 1977·The Journal of Allergy and Clinical Immunology·J W JenneF J Wall
Mar 1, 1979·Clinical and Experimental Pharmacology & Physiology·G K TerpstraJ Kreukniet
Sep 1, 1977·Prostaglandins·J SvenssenM Hamberg
Feb 1, 1975·Life Sciences·M HambergB Samuelsson
Jan 1, 1974·Annual Review of Medicine·R Patterson, J F Kelly
Dec 11, 1974·Biochemical and Biophysical Research Communications·M Hamberg, B Samuelsson
Feb 1, 1969·Archives of Disease in Childhood·K Aas
Mar 1, 1972·Clinica Chimica Acta; International Journal of Clinical Chemistry·M A BeavenZ Horáková
Jun 22, 1968·Nature·N GilmoreJ H Wyllie

❮ Previous
Next ❯


Sep 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·A J SchreursF P Nijkamp
Oct 1, 1984·Agents and Actions·A J Schreurs, F P Nijkamp
Feb 1, 1984·Veterinary Research Communications·A J Schreurs, F P Nijkamp
Jan 28, 1983·European Journal of Pharmacology·A J SchreursF P Nijkamp
Jan 1, 1987·Annals of the New York Academy of Sciences·A J Van Oosterhout, F P Nijkamp
Dec 1, 1988·Journal of Veterinary Pharmacology and Therapeutics·P O OgunbiyiP Eyre
Nov 1, 1988·Prostaglandins, Leukotrienes, and Essential Fatty Acids·C LoesbergF P Nijkamp
Jul 1, 1981·The Journal of Pharmacy and Pharmacology·A A Norris, P Eyre

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.


Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.


This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.