The effects of Haemophilus influenzae vaccination on anaphylactic mediator release and isoprenaline-induced inhibition of mediator release

European Journal of Pharmacology
A J SchreursF P Nijkamp

Abstract

The influence of Haemophilus influenzae on anaphylactic mediator release from ovalbumin-sensitized isolated guinea pig lungs was investigated. Lungs from H. influenzae-vaccinated animals released prostaglandins and thromboxanes following a smaller dose of ovalbumin than was effective in non-vaccinated animals. Histamine release was significantly increased in 4 day-vaccinated animals but not 1 or 10 days after vaccination, while broncho-constriction was potentiated in 1 and in 4 day-vaccinated animals. This increased histamine release was achieved following 2 micrograms ovalbumin. In contrast, doses of 10 micrograms and 1 mg ovalbumin respectively did not affect and decreased histamine release in the vaccinated group. The inhibition of anaphylactic mediator release by an infusion of 6 x 10(-9) M isoprenaline was significantly attenuated by H. influenzae vaccination. These results indicate an increased sensitivity to antigenic challenge and suggest that the functioning of beta-adrenoceptors was decreased as a result of H. influenzae vaccination.

References

Dec 1, 1977·The Journal of Allergy and Clinical Immunology·J W JenneF J Wall
Mar 1, 1979·Clinical and Experimental Pharmacology & Physiology·G K TerpstraJ Kreukniet
Sep 1, 1977·Prostaglandins·J SvenssenM Hamberg
Feb 1, 1975·Life Sciences·M HambergB Samuelsson
Jan 1, 1974·Annual Review of Medicine·R Patterson, J F Kelly
Dec 11, 1974·Biochemical and Biophysical Research Communications·M Hamberg, B Samuelsson
Feb 1, 1969·Archives of Disease in Childhood·K Aas
Mar 1, 1972·Clinica Chimica Acta; International Journal of Clinical Chemistry·M A BeavenZ Horáková
Jun 22, 1968·Nature·N GilmoreJ H Wyllie

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Citations

Sep 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·A J SchreursF P Nijkamp
Oct 1, 1984·Agents and Actions·A J Schreurs, F P Nijkamp
Feb 1, 1984·Veterinary Research Communications·A J Schreurs, F P Nijkamp
Jan 28, 1983·European Journal of Pharmacology·A J SchreursF P Nijkamp
Jan 1, 1987·Annals of the New York Academy of Sciences·A J Van Oosterhout, F P Nijkamp
Dec 1, 1988·Journal of Veterinary Pharmacology and Therapeutics·P O OgunbiyiP Eyre
Nov 1, 1988·Prostaglandins, Leukotrienes, and Essential Fatty Acids·C LoesbergF P Nijkamp
Jul 1, 1981·The Journal of Pharmacy and Pharmacology·A A Norris, P Eyre

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