The effects of heart failure on renal function.

Cardiology Clinics
Suneel M Udani, Jay L Koyner

Abstract

Heart-kidney interactions have been increasingly recognized by clinicians and researchers who study and treat heart failure and kidney disease. A classification system has been developed to categorize the different manifestations of cardiac and renal dysfunction. Work has highlighted the significant negative prognostic effect of worsening renal function on outcomes for individuals with heart failure. The etiology of concomitant cardiac and renal dysfunction remains unclear; however, evidence supports alternatives to the established theory of underfilling, including effects of venous congestion and changes in intra-abdominal pressure. Conventional therapy focuses on blockade of the renin-angiotensin-aldosterone system with expanding use of direct renin and aldosterone antagonists. Novel therapeutic interventions using extracorporeal therapy and antagonists of the adenosine pathway show promise and require further investigation.

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Citations

Aug 25, 2012·Current Heart Failure Reports·Filippos K Triposkiadis, John Skoularigis
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Dec 31, 2019·Journal of Food and Drug Analysis·Chih Yang HuangWan Teng Lin

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