The Effects of Helicobacter pylori Eradication Therapy for Chronic IdiopathicThrombocytopenic Purpura

Gut and Liver
Jae Jin HwangNayoung Kim

Abstract

The aim of this study was to evaluate the ability of Helicobacter pylori eradication treatment to increase platelet counts in Korean patients with chronic idiopathic thrombocytopenic purpura (ITP). A total of 102 patients were evaluated against two criteria. First, those diagnosed with H. pylori infections in whom eradication was successful were assigned to the H. pylori-positive and -eradicated group (n=39), whereas those diagnosed with H. pylori infections in whom eradication failed were assigned to the H. pylori-positive and -non-eradicated group (n=3), and those without H. pylori infections were assigned to the H. pylori - negative group (n=60). Second, patients with complete remission in whom the platelet recovery effect was maintained over the average follow-up period of 6 months after eradication therapy were defined as the responder group (n=58), whereas those with partial or no response were defined as the nonresponder group (n=44). The platelet counts of the H. pylori-positive and -eradicated group were significantly increased 6 months after eradication therapy compared to those of the H. pylori-positive and -non-eradicated group and the H. pylori-negative group (43.2±29.1 to 155.3±68.7×10³/μL vs 42.5±28.1 to 79.8±59....Continue Reading

References

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Citations

Jun 8, 2018·Experimental Animals·Teruko FukudaKazuo Goto
Apr 19, 2018·Arquivos De Gastroenterologia·Luiz Gonzaga Vaz CoelhoJoaquim Prado de Moraes-Filho
Jul 26, 2018·Arquivos De Gastroenterologia·Luiz Gonzaga Vaz CoelhoJosé Vitor Zir
Mar 13, 2021·Blood Research·Seyed Mohammad Sadegh PezeshkiArshid Yousefi Avarvand

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