The Effects of High Fat Diet-Induced Stress on Olfactory Sensitivity, Behaviors, and Transcriptional Profiling in Drosophila melanogaster

International Journal of Molecular Sciences
Jewon JungHyung Wook Kwon

Abstract

High-fat diet (HFD) often causes obesity and it has detrimental effects on the sensory system. In particular, sensory-mediated responses are crucial for maintaining energy balance, as they are involved in a metabolic regulation; however, there is still no clear explanation about the relationship between HFD-induced stress and sensory system. To gain insight on how HFD-induced stress affects olfactory sensitivity and behavioral responses, we have used a Drosophila melanogaster model for olfactory and nutrient-related signaling and accessed physiological, behavioral, and transcriptional changes. We demonstrated that lifespan and climbing ability in HFD-treated flies decreased and that olfactory sensitivity and behavioral responses to odorants were changed. Olfactory sensitivity to eight of ten odorants after 14 days on HFD treatment were reduced, while behavioral attraction was increased to benzaldehyde in flies that were treated with HFD. This behavioral and physiological modification in HFD-treated flies for 14 days was accompanied by a significant decrease in DmOrco gene expression in a peripheral olfactory organ, suggesting that is could be involved in the action of metabolic and sensory signal. Gene expression profiles of an...Continue Reading

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Citations

Feb 28, 2019·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Osvaldo RiveraMatthew E Talbert
Sep 10, 2020·International Journal of Molecular Sciences·Ahmed M El-ShehawiMona M Elseehy
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Jul 1, 2021·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Julia Sepel LoretoNilda Vargas Barbosa

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Datasets Mentioned

BETA
SRR1501071
SRR1501074

Methods Mentioned

BETA
PCR
dissection

Software Mentioned

StepOne plus
R
edgeR bioconductor package
EAG Pro
DAVID
RSEM
SPSS

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