PMID: 7015926Jun 1, 1981Paper

The effects of high-frequency positive-pressure ventilation on intracranial pressure and brain surface movement in cats

Anesthesiology
M M ToddH M Shapiro

Abstract

Compared to traditional, low-frequency ventilation (LFV), mechanical ventilation at high frequencies (60-200 breaths/min) and low tidal volumes (HFV) is known to: 1) eliminate respiratory-synchronous variations in blood pressure; 2) minimize ventilatory effects on the cardiovascular system; 3) reduce peak airway pressures; and 4) suppress spontaneous respiratory efforts. Since these and other properties may make HFV useful in patients with acute intracranial pathology, we studied the effects of HFV on intracranial pressure (ICP) in cats. Compared with LFV (rate 11/min, tidal volume equals 15 ml/kg), HFV (rate 100/min, VT equals 3.3 ml/kg) had little effect on mean arterial pressure, heart rate, right atrial pressure, mean ICP or mean cerebral perfusion pressures, even if baseline ICP was raised using an epidural balloon. However, HFV effectively eliminated ventilator-linked fluctuations in both blood pressure and ICP, and at all levels of mean ICP studied (4.8, 15, and 30 torr), significantly reduced the peak ICP seen during a single respiratory cycle. The reduction in ICP fluctuation and peak pressure was more pronounced as intracranial complicance fell. However, the physiologic significance of such a change in the ICP pressur...Continue Reading

Citations

Jan 1, 1984·Biulleten' eksperimental'noĭ biologii i meditsiny·E P Vovenko
Aug 13, 2008·Neurocritical Care·Paul NyquistMarek A Mirski
Aug 1, 1984·Respiration Physiology·H K Chang, A Harf
Jul 1, 1988·The American Review of Respiratory Disease·A S Slutsky
Dec 1, 1983·AORN Journal·S F QuanC K Waterson
Aug 22, 2006·Journal of Neural Engineering·Aaron Gilletti, Jit Muthuswamy

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