The effects of high glucose and atorvastatin on endothelial cell matrix production

Diabetic Medicine : a Journal of the British Diabetic Association
S McGinnC A Pollock

Abstract

Statins are known to enhance atherosclerotic plaque stability through influences on extracellular matrix homeostasis. Net matrix production reflects the relative balance of matrix production and degradation through enzymes such as matrix metalloproteinases (MMPs) and their inhibitors, tissue inhibitor of MMP (TIMPs). The effects of statins on endothelial cell production of these parameters following co-exposure with a proatherogenic stimulus such as high glucose are not known. Human endothelial cells were exposed for 72 h to 5 mm (control) or 25 mm (high) glucose +/- atorvastatin (1 micromol/l). Extracellular matrix homeostasis was assessed by measuring matrix metalloproteinase (MMP)-2 secretion, tissue inhibitor of MMP (TIMP)-1 and -2 secretion and net collagen IV production. Results were expressed as percentage +/- SEM of control values. Exposure to high glucose increased cellular collagen IV expression to 190.1 +/- 11.7% (P < 0.0001) of control levels. No change in MMP-2 secretion (111.6 +/- 5.2%; P > 0.05) was observed but both TIMP-1 and TIMP-2 expression were increased to 136.3 +/- 6.4% and 144.0 +/- 27.5%, respectively (both P < 0.05). The presence of atorvastatin in high glucose conditions reduced collagen IV expression...Continue Reading

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Citations

Oct 17, 2015·International Journal of Molecular Sciences·Sara CasellaAugusto Orlandi
Jul 17, 2015·Journal of Applied Toxicology : JAT·Yue ZhangDavid J Tollerud
Sep 22, 2016·Naunyn-Schmiedeberg's Archives of Pharmacology·Stefanie KlenkeUlrich H Frey
Aug 16, 2013·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Yu Mi HaYoung Jin Kang
Jul 18, 2014·Journal of Biomechanical Engineering·Dannielle S FigueroaAlisa Morss Clyne
Apr 29, 2005·Diabetes/metabolism Research and Reviews

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