PMID: 3769905Jan 1, 1986Paper

The effects of high intensity exercise on muscle and plasma levels of alpha-ketoisocaproic acid

European Journal of Applied Physiology and Occupational Physiology
R A FieldingB R Bistrian

Abstract

Alpha-ketoisocaproic acid (KIC) is the product of the transamination of the indispensable amino acid leucine, which is the first step in the complete degradation of leucine. To determine the effects of intense exercise on muscle and blood levels of KIC, 7 male volunteers performed cycle exercise to exhaustion. After pedaling at an intensity of 90 W for 3 min, the load was increased by 60 W every 3 min until volitional fatigue. Muscle biopsies were obtained prior to and immediately after exercise and rapidly frozen for later determination of KIC. During exercise, blood lactate levels increased as expected, while plasma KIC levels did not change. Following exercise, plasma KIC levels rose significantly with peak values occurring 15 min after exercise and did not return to pre-exercise values until 60 min after exercise. In contrast, muscle KIC levels increased during exercise from a pre-exercise mean of 49.4 +/- 4.1 mumol X kg-1 wet wt to 78.1 +/- 6.5 mumol X kg-1 after exercise, an average increase of 48% (P less than 0.05). These data indicate that during intense exercise, leucine transamination in muscle may continue at a faster rate than the decarboxylation of KIC. In addition, plasma levels of KIC did not reflect the intrace...Continue Reading

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Citations

May 23, 2012·Scandinavian Journal of Medicine & Science in Sports·M EsbjörnssonE Jansson
Aug 13, 2013·Research Quarterly for Exercise and Sport·Benjamin WaxLaura Hilton
Apr 6, 2004·Medicine and Science in Sports and Exercise·Britni N Buford, Alexander J Koch
Sep 17, 2014·Journal of Strength and Conditioning Research·Benjamin WaxJoseph Sperlak
Jun 1, 1991·The American Journal of Physiology·A J WagenmakersW H Saris
Jan 1, 1989·European Journal of Applied Physiology and Occupational Physiology·A J WagenmakersR H Edwards
Dec 29, 2000·Medicine and Science in Sports and Exercise·B R StevensR W Braith
Jan 1, 1990·The American Journal of Physiology·M Yagi, M Walser
Jun 22, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Krista R HowarthMartin J Gibala
Aug 7, 2021·Frontiers in Physiology·Gagandeep MannOlasunkanmi A J Adegoke

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