The Effects of High-Protein Diets on Kidney Health and Longevity.

Journal of the American Society of Nephrology : JASN
Gang-Jee KoShivam Joshi

Abstract

Although high-protein diets continue to be popular for weight loss and type 2 diabetes, evidence suggests that worsening renal function may occur in individuals with-and perhaps without-impaired kidney function. High dietary protein intake can cause intraglomerular hypertension, which may result in kidney hyperfiltration, glomerular injury, and proteinuria. It is possible that long-term high protein intake may lead to de novo CKD. The quality of dietary protein may also play a role in kidney health. Compared with protein from plant sources, animal protein has been associated with an increased risk of ESKD in several observational studies, including the Singapore Chinese Health Study. Potential mediators of kidney damage from animal protein include dietary acid load, phosphate content, gut microbiome dysbiosis, and resultant inflammation. In light of such findings, adopting current dietary approaches that include a high proportion of protein for weight reduction or glycemic control should be considered with care in those at high risk for kidney disease. Given the possibility of residual confounding within some observational studies and the conflicting evidence from previous trials, long-term studies including those with large sa...Continue Reading

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Citations

Dec 29, 2020·Journal of Cellular and Molecular Medicine·Li YinHui Huang
Dec 17, 2020·Current Opinion in Clinical Nutrition and Metabolic Care·Yoko NarasakiKamyar Kalantar-Zadeh
Mar 21, 2021·The American Journal of Clinical Nutrition·Yoko NarasakiConnie M Rhee
Jul 3, 2020·Nutrients·Kamyar Kalantar-ZadehCsaba P Kovesdy
Oct 28, 2020·Journal of Obesity & Metabolic Syndrome·Ju Young Kim
May 16, 2021·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Connie M RheeLinda W Moore
May 28, 2021·Frontiers in Nutrition·Qi Su, Qin Liu
Jun 28, 2021·Lancet·Kamyar Kalantar-ZadehVlado Perkovic
Jul 27, 2021·Frontiers in Medicine·Ekamol TantisattamoBiruh T Workeneh
Jun 22, 2021·The Korean Journal of Internal Medicine·Gang-Jee Ko, Kamyar Kalantar-Zadeh
Nov 14, 2020·Current Opinion in Nephrology and Hypertension·Ekamol TantisattamoKlemens Budde

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