PMID: 1201375Oct 1, 1975Paper

The effects of histamine and some histamine-like agonists on blood pressure in the cat

British Journal of Pharmacology
D A Owen

Abstract

1. The effects of histamine on blood pressure have been compared with the effects caused by four histamine-like agonists in anaesthetized cats. 2. It has been confirmed that the depressor responses to histamine involve both H1- and H2-receptors: depressor responses also follow the administration of selective H1- and H2-receptor agonists. 3. 2-Methylhistamine, in doses up to 1 X 10(-7) mol/kg, lowers blood pressure by interaction with H1-receptors. Larger doses of 2-methylhistamine also lower blood pressure but this may involve H2-receptors. 4. 4-Methylhistamine, in doses up to 1 X 10(-7) mol/kg, lowers blood pressure by interaction with H2-receptors. Larger doses of 4-methylhistamine also lower blood pressure but this may involve H1-receptors. 5. 2-(2-Aminoethyl)pyridine and 2-(2-aminoethyl)thiazole both lower blood pressure by interaction with H1-receptors only. 6. The potential value and limitations of these compounds as tools to investigate the cardiovascular effects of histamine are discussed.

References

Sep 1, 1975·Journal of Medicinal Chemistry·G J DurantM E Parsons
Oct 1, 1975·British Journal of Pharmacology·S B Flynn, D A Owen
Jun 1, 1974·The Australian Journal of Experimental Biology and Medical Science·P R carrollN Latt
Feb 1, 1966·The Journal of Pharmacy and Pharmacology·T M Jones, N Pilpel
Apr 21, 1972·Nature·J W BlackE M Parsons

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Citations

Aug 1, 1979·Agents and Actions·M Hagen, I Paegelow
Dec 1, 1979·Agents and Actions·B I HirschowitzA L Waldo
Oct 1, 1978·Agents and Actions·D C CarterM I Grossman
Sep 1, 1977·European Journal of Pharmacology·A TuckerJ T Reeves
Jan 1, 1977·General Pharmacology·D A Owen
Jul 1, 1986·Diagnostic Microbiology and Infectious Disease·J D OliverK Linder
Oct 1, 1975·British Journal of Pharmacology·S B Flynn, D A Owen
Sep 1, 1977·British Journal of Pharmacology·S B FlynnD A Owen
Aug 1, 1979·British Journal of Pharmacology·J R Powell, L B Shamel
Sep 1, 1979·The Journal of Pharmacy and Pharmacology·D A OwenR W Gristwood
Jan 1, 1978·Clinical and Experimental Hypertension : CHE·P E Hicks
Oct 1, 1984·British Journal of Pharmacology·C A Harvey, D A Owen
May 1, 1980·Microvascular Research·P H GuthE Smith

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