The effects of histamine on responses of the rabbit ear artery to electrical stimulation and to exogenous noradrenaline

British Journal of Pharmacology
A Foldes, R C Hall


1 The effects of a subconstrictor dose of histamine (9 x 10(-7) mol/l) on the responses of the isolated perfused ear artery of the rabbit to electrical stimulation (E.S.) and to exogenous noradrenaline (NA) were investigated.2 Both intraluminal (I/L) and extraluminal (E/L) histamine potentiated responses to E.S. and to I/L NA to the same extent.3 Mepyramine alone (2.5 x 10(-6) mol/l) had no effect on the response of the ear artery to either stimulus, but in the presence of this concentration of mepyramine, the potentiation by histamine of the response to I/L NA was significantly decreased and that to E.S. was replaced by inhibition.4 The H(1)-receptor agonist, 2(2-pyridyl) ethylamine, applied I/L potentiated responses to I/L NA at both concentrations used (5.1 and 51 x 10(-7) mol/l), but only potentiated the effects of E.S. at the higher concentration.5 The H(2)-receptor antagonist, metiamide (4 x 10(-6) mol/l), alone did not alter the extent of potentiation of responses to either E.S. or I/L NA by histamine. This suggests relatively weak H(2)-receptor activity in the rabbit ear artery. In the presence, but not the absence of metiamide, the potentiation by histamine of the I/L NA response was reversible, an observation suggesti...Continue Reading


Jan 1, 1988·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·T TaneikeA Ohga
Jan 1, 1981·General Pharmacology·S PatelS C Verma
Jun 1, 1981·Journal of Autonomic Pharmacology·I Marshall
Feb 1, 1992·Journal of Autonomic Pharmacology·F J MirandaE Alborch
Jan 1, 1982·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P M Gross
Jan 4, 2013·PloS One·Patrick J AtkinsonRachael T Richardson
Jul 1, 1987·Medicinal Research Reviews·P B Timmermans, M J Thoolen


Sep 1, 1975·Journal of Medicinal Chemistry·G J DurantM E Parsons
Feb 1, 1977·British Journal of Pharmacology·P R Carroll, W E Glover
Feb 1, 1977·The Australian Journal of Experimental Biology and Medical Science·A FoldesI S De La Lande
Oct 1, 1965·The Australian Journal of Experimental Biology and Medical Science·I S De La Lande, M J Rand
Aug 1, 1972·Canadian Journal of Physiology and Pharmacology·H E Brezenoff, S B Gertner
Jan 1, 1974·Acta Physiologica Scandinavica·B Ehinger
Dec 1, 1966·British Journal of Pharmacology and Chemotherapy·I S De La LandeJ G Waterson

Related Concepts

Muscle, Smooth, Vascular
Histamine Measurement
Presynaptic Terminals
Arterial System
Affect (Mental Function)
Antagonist Muscle Action
Action Potentials
Regional Blood Flow

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.