The effects of histamine on responses of the rabbit ear artery to electrical stimulation and to exogenous noradrenaline

British Journal of Pharmacology
A Foldes, R C Hall

Abstract

1 The effects of a subconstrictor dose of histamine (9 x 10(-7) mol/l) on the responses of the isolated perfused ear artery of the rabbit to electrical stimulation (E.S.) and to exogenous noradrenaline (NA) were investigated.2 Both intraluminal (I/L) and extraluminal (E/L) histamine potentiated responses to E.S. and to I/L NA to the same extent.3 Mepyramine alone (2.5 x 10(-6) mol/l) had no effect on the response of the ear artery to either stimulus, but in the presence of this concentration of mepyramine, the potentiation by histamine of the response to I/L NA was significantly decreased and that to E.S. was replaced by inhibition.4 The H(1)-receptor agonist, 2(2-pyridyl) ethylamine, applied I/L potentiated responses to I/L NA at both concentrations used (5.1 and 51 x 10(-7) mol/l), but only potentiated the effects of E.S. at the higher concentration.5 The H(2)-receptor antagonist, metiamide (4 x 10(-6) mol/l), alone did not alter the extent of potentiation of responses to either E.S. or I/L NA by histamine. This suggests relatively weak H(2)-receptor activity in the rabbit ear artery. In the presence, but not the absence of metiamide, the potentiation by histamine of the I/L NA response was reversible, an observation suggesti...Continue Reading

References

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Citations

Sep 1, 1975·Journal of Medicinal Chemistry·G J DurantM E Parsons
Feb 1, 1977·British Journal of Pharmacology·P R Carroll, W E Glover
Feb 1, 1977·The Australian Journal of Experimental Biology and Medical Science·A FoldesI S De La Lande
Oct 1, 1965·The Australian Journal of Experimental Biology and Medical Science·I S De La Lande, M J Rand
Aug 1, 1972·Canadian Journal of Physiology and Pharmacology·H E Brezenoff, S B Gertner
Jan 1, 1974·Acta Physiologica Scandinavica·B Ehinger
Dec 1, 1966·British Journal of Pharmacology and Chemotherapy·I S De La LandeJ G Waterson

Related Concepts

Muscle, Smooth, Vascular
Histamine Measurement
Presynaptic Terminals
Arterial System
Pyrilamine
Affect (Mental Function)
Antagonist Muscle Action
Action Potentials
Regional Blood Flow
Intraluminal

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