PMID: 2864321Jan 1, 1985

The effects of homogeneous human prealbumin on in vitro and in vivo immune responses in the mouse

International Journal of Immunopharmacology
P BurtonA White

Abstract

A highly purified preparation of human prealbumin was shown to potentiate the sensitivity of rosette spleen forming cells of adult thymectomized mice to azathioprine in vitro and in vivo and to induce the appearance of the Thy 1, 2 antigen in vitro on spleen cells of adult thymectomized mice. Prealbumin also enhanced IgM antibody synthesis to sheep red blood cells (SRBC) in vitro in 12 week old mice and in vivo in aged (45 - 58 week old) and nude (nu/nu) mice. In vivo administration, to mice that had been pre-treated with hydrocortisone, resulted in a decrease in the specific activity of thymocyte terminal deoxynucleotidyl transferase. The data indicate that the prealbumin molecule possesses immunopotentiating properties in a number of in vitro and in vivo immunocompromised murine models and that the immuno-enhancing properties of the partially purified preparation previously described were in fact due to the prealbumin component and not to other contaminating proteins.

References

Feb 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·P BurtonA White
Jan 1, 1979·Annals of the New York Academy of Sciences·A White, P Burton
Feb 14, 1978·Biochemical and Biophysical Research Communications·E G BliznakovK Folkers
Feb 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·T L LowA L Goldstein

Citations

Jan 30, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·J A Palha
Jan 16, 1989·Biochemical and Biophysical Research Communications·T PetterssonH Jörnvall
Oct 12, 2011·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·A P LouppisM G Kontominas
Nov 1, 1991·Annals of the Rheumatic Diseases·B Zurier

Related Concepts

Immunologic Adjuvants
Metazoa
Antibody Formation
Surface Antigens
Blood Group Antigens
Tdt Antigen
Hydrocortisone, (9 beta,10 alpha,11 alpha)-Isomer
Mice, Inbred C57BL
Mice, Nude
Prealbumin

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