The Effects of Housing Density on Social Interactions and Their Correlations with Serotonin in Rodents and Primates

Scientific Reports
Young-A LeeYukiori Goto

Abstract

Population density has been suggested to affect social interactions of individuals, but the underlying neural mechanisms remain unclear. In contrast, neurotransmission of monoamines such as serotonin (5-HT) and dopamine (DA) has been demonstrated to play important roles in social behaviors. Here, we investigated whether housing density affected social interactions of rodents and non-human primates housed in groups, and its correlations with monoamines. Japanese macaques exhibited higher plasma 5-HT, but not DA, concentrations than rhesus macaques. Similarly, C57BL/6 mice exhibited higher plasma and brain tissue 5-HT concentrations than DBA2 mice. Under crowding, C57BL/6 mice and Japanese macaques exhibited more prominent social avoidance with mates than DBA2 mice and rhesus macaques, respectively. Although DBA2 mice and rhesus macaques in crowding exhibited elevated plasma stress hormones, such stress hormone elevations associated with crowding were absent in C57BL/6 mice and Japanese macaques. Administration of parachlorophenylalanine, which inhibits 5-HT synthesis, increased social interactions and stress hormones in C57BL/6 mice under crowding. These results suggest that, animals with hyperserotonemia may exhibit social avoi...Continue Reading

References

Oct 1, 1977·Pharmacology, Biochemistry, and Behavior·R R GriffithsI Liebson
Jan 1, 1989·Psychopharmacology·L E AnnettH F Baker
Sep 1, 1989·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·B A EllenbroekA R Cools
Jan 1, 1985·Pharmacology, Biochemistry, and Behavior·E O Smith, L D Byrd
Jan 1, 1974·Behaviour·J Altmann
Mar 13, 1970·Science·S Milgram
Feb 1, 1984·Pharmacology, Biochemistry, and Behavior·E O Smith, L D Byrd
Mar 1, 1994·Pharmacology, Biochemistry, and Behavior·R E SteinpreisJ D Salamone
Dec 1, 1995·Physiology & Behavior·K J Brown, N E Grunberg
Jan 1, 1997·American Journal of Primatology·F Aureli, F B de Waal
Nov 14, 1997·Neuroscience and Biobehavioral Reviews·A Marchlewska-Koj
Mar 21, 1998·The American Journal of Psychiatry·B KnutsonV I Reus
Jun 3, 1998·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·F Sams-Dodd
Mar 29, 2001·Behavioural Brain Research·E T Larson, C H Summers
Jan 5, 2002·Neuron·U Frith
Jun 16, 2004·Behavioural Brain Research·Isabelle C WeissJoram Feldon
Apr 4, 2007·Archives of Pediatrics & Adolescent Medicine·Lisa A CroenJudith K Grether
Jul 13, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·William P MelegaLynn A Fairbanks
Mar 11, 2009·Bulletin of the World Health Organization·Edmund Ramsden
May 21, 2009·Nature Reviews. Neuroscience·Amy F T Arnsten
Sep 25, 2010·Pharmacology, Biochemistry, and Behavior·Kathryn K Chadman
Feb 4, 2011·Pediatric Research·Elysa J MarcoSrikantan S Nagarajan
Dec 31, 2011·Neuroscience and Biobehavioral Reviews·Dominik KiserJudith R Homberg
Jan 24, 2012·Methods in Enzymology·Erik MeijeringIhor Smal
Mar 21, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jeremy Veenstra-VanderWeeleRandy D Blakely
Apr 25, 2012·Psychopharmacology·Margaret C WardleHarriet de Wit
Jun 29, 2013·Journal of Autism and Developmental Disorders·Marlene B LauritsenErik T Parner
Sep 10, 2013·ELife·Yair ShemeshElad Schneidman
Jan 11, 2014·International Journal of Epidemiology·Selma IdringBrian K Lee
Mar 13, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Stefano GabrieleAntonio M Persico
Dec 3, 2014·Psychoneuroendocrinology·En-Ju D LinMatthew J During
Jan 6, 2015·Research in Autism Spectrum Disorders·Kimberly B SchauderCarissa J Cascio
Nov 19, 2015·Neuroscience·C L MullerJ Veenstra-VanderWeele
Jul 28, 2016·Physiology & Behavior·Young-A LeeYukiori Goto
Dec 9, 2016·The International Journal of Neuropsychopharmacology·Yoshie YamaguchiYukiori Goto

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Citations

Sep 9, 2018·Disease Models & Mechanisms·John P Sundberg, Paul N Schofield
Oct 1, 2020·Cellular and Molecular Life Sciences : CMLS·Anne-Kathrin GellnerRené Hurlemann
Jul 18, 2020·Scientific Reports·Yui AsaokaYukiori Goto
Apr 10, 2021·Journal of Chemical Neuroanatomy·Danielle N Jones, Mary Ann Raghanti
Apr 27, 2021·Behavioural Brain Research·Young-A LeeYukiori Goto

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA
Protein Assay

Software Mentioned

MTrackJ
Origin Pro
ImageJ
Statistica

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