The effects of human amniotic membrane and fibrin sealant in the prevention of postoperative adhesion formation in the rabbit ovary model

The Australian & New Zealand Journal of Obstetrics & Gynaecology
S OzerenO Karabacak

Abstract

The study group consisted of 29 female, white New Zealand rabbits. The rabbits were randomized into 3 groups and a midline laparotomy was performed in order to make a 4-5 mm long lesion using a scalpel in both ovaries. In Group 1, both of the ovaries were left uncovered. In Group 2, the right ovaries were covered by human amniotic membrane graft. In Group 3, 0.1-0.2 mL of Tisseel solution was applied to the lesion in the right ovaries. No medication was applied to the left ovaries in any of the groups and thus this ovary acted as an individual control. After 2 weeks the adhesion scores were graded by relaparotomy in a blind manner. Fibrin sealant showed a significant reduction in postoperative adhesion formation compared with the amniotic membrane graft and control groups (p<0.001). Therefore, it can be concluded that fibrin sealant can be used as an adjuvant during reproductive surgery.

Citations

Nov 4, 2000·Expert Opinion on Investigational Drugs·R A Clark
Jun 15, 2004·Fertility and Sterility·Michael P DiamondGhassan M Saed
Jun 17, 2015·BioMed Research International·Mari MatobaAkeo Hagiwara
Jan 23, 2004·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·David WisemanIsrael Nur
Sep 30, 2004·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Ghassan M SaedMichael P Diamond
May 21, 2015·Revista do Colégio Brasileiro de Cirurgiões·Rafael Calvão BarbutoIan Göedert Leite Duarte

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