The effects of hydrocortisone on cognitive and neural function: a behavioral and event-related potential investigation

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Christopher S Monk, Charles A Nelson

Abstract

Research indicates that glucocorticoids affect hippocampal function and the form of cognition that the hippocampus is thought to subserve, explicit memory. However, some studies suggest that glucocorticoids affect the frontal lobe, attention and working memory. Thus, it is not clear whether glucocorticoids specifically target the hippocampus and explicit memory or if the effects are more ubiquitous. By simultaneously measuring event-related potentials and behavioral performance in tasks designed to tap particular cognitive and neural processes, the present study examined the effects of hydrocortisone on 24 healthy humans. In an intentional face recognition memory task where the stimuli were presented again after a brief delay (6-18 s) and a long delay (30 min), hydrocortisone altered the P600 component (an electrophysiological index of recognition memory and hippocampal activity) following the brief delay and impaired behavioral performance after the long delay. ERPs and behavioral performance were not affected in the attention and working memory tasks. These findings are consistent with reports indicating that glucocorticoids affect explicit memory and hippocampal function.

Citations

Dec 25, 2010·Psychopharmacology·Sonja RömerHartmut Schächinger
Oct 10, 2002·Biological Psychiatry·Daniel Pine, Dennis Charney
Jun 24, 2003·Physiology & Behavior·Frances ConnanJanet Treasure
May 1, 2011·Development and Psychopathology·Inge-Marie EigstiB J Casey
Nov 20, 2012·Journal of the International Neuropsychological Society : JINS·Christine MrakotskyDeborah P Waber
Mar 30, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rachel YehudaJames Schmeidler
Mar 26, 2011·Proceedings of the National Academy of Sciences of the United States of America·Marloes J A G HenckensGuillén Fernández
Jul 30, 2005·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Robert D AnnettRobert C Strunk
Aug 23, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·C SfagosA D Rabavilas
May 20, 2005·Journal of Clinical Child and Adolescent Psychology : the Official Journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53·Rebecca J JohnsonLaura A McCloskey
Apr 3, 2009·Neurobiology of Learning and Memory·Roman DunckoChristian Grillon
Jun 21, 2006·Child: Care, Health and Development·M SimsT S Parry
Sep 29, 2011·Human Psychopharmacology·Leonardo José VazSabine Pompéia
Sep 9, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Charalabos C PapageorgiouConstantin R Soldatos
Mar 18, 2006·Human Brain Mapping·Kevin D TessnerStephan Hamann
Jul 3, 2013·Stress and Health : Journal of the International Society for the Investigation of Stress·Joan FornsJordi Sunyer
Mar 15, 2013·Stress : the International Journal on the Biology of Stress·Melissa R StaubleGin Morgan
Apr 17, 2012·Psychoneuroendocrinology·Magdalena BuckertChristian J Fiebach
Jul 6, 2016·Journal of Cognitive Neuroscience·Lisa J WeckesserRobert Miller
Oct 25, 2008·Arquivos de neuro-psiquiatria·Juliana Nery de Souza-TalaricoEliane Corrêa Chaves
Nov 26, 2010·Journal of Psychopharmacology·Hamid AlhajR Hamish McAllister-Williams
Sep 24, 2015·Psychology of Music·Cynthia M KilloughGin Morgan
Jan 22, 2008·The International Journal of Neuroscience·Tiffany FieldMaria Hernandez-Reif
Jan 1, 2005·Nonlinearity in Biology, Toxicology, Medicine·Sonia J LupienJens Pruessner

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