The effects of hyperbaric oxygen on macrophage polarization after rat spinal cord injury

Brain Research
Cheng-Kui GengHua-Lin Yu

Abstract

The immunoreactive responses are a two-edged sword after spinal cord injury (SCI). Macrophages are the predominant inflammatory cells responsible for this response. However, the mechanism underlying the effects of HBOT on the immunomodulation following SCI is unclear now. The present study was performed to examine the effects of hyperbaric oxygen therapy (HBOT) on macrophage polarization after the rat compressive injury of the spinal cord. HBOT was associated with significant increases in IL-4 and IL-13 levels, and reductions in TNF-α and IFN-ɣ levels. This was associated simultaneously with the levels of alternatively activated macrophages (M2 phenotype: arginase-1- or CD206-positive), and decreased levels of classically activated macrophages (M1 phenotype: iNOS- or CD16/32-positive). These changes were associated with functional recovery in the HBOT-transplanted group, which correlated with preserved axons and increased myelin sparing. Our results suggested that HBOT after SCI modified the inflammatory environment by shifting the macrophage phenotype from M1 to M2, which may further promote the axonal extension and functional recovery.

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Citations

Apr 20, 2019·Scandinavian Journal of Immunology·Caiyun QianDaya Luo
Apr 24, 2019·International Journal of Molecular Sciences·Zong-Sheng WuShu-Hung Huang
Feb 17, 2018·Neural Regeneration Research·Kyriakos DalamagkasAlexander M Seifalian
Jul 5, 2017·BMC Neurology·Yongming SunQifeng Tang
Sep 10, 2020·Biomolecules·Blaise CozeneCesar V Borlongan

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