PMID: 8957202Nov 1, 1996Paper

The effects of hyperinsulinaemia on myocardial mass, blood pressure regulation and central haemodynamics in rats

European Journal of Clinical Investigation
A HolmängP Björntorp

Abstract

Left ventricular hypertrophy is a condition with high mortality. An association with insulin resistance and hyperinsulinaemia has recently been suggested. The aim of this study was to examine the effects of isolated hyperinsulinaemia on cardiac weight and haemodynamic regulation. Rats were exposed to hyperinsulinaemia for 7 weeks after adrenalectomy with corticosterone substitution and continuous infusion of propranolol to control counter-regulatory mechanism (n = 15) (AIP group). Hypoglycaemia was prevented by glucose in the drinking water. Hyperinsulinaemic (AIP) rats were heavier and had increased relative masses of the myocardium (left ventricle 17% and right ventricle 20%), kidneys and adipose tissues in comparison with normoinsulinaemic adrenalectomized, corticosterone- and propranolol-treated controls (AP) (n = 10). Blood pressure in the insulin-exposed animals, measured weekly by the tail-cuff method in conscious rats, was not different from (AP) controls over 5 weeks, but increased in the sixth week. At the end of the seventh experimental week, blood pressure measured intra-arterially was also found to be elevated. Heart rate was not changed but total peripheral resistance was about twice that of controls (P < 0.001). ...Continue Reading

Citations

May 23, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Berna Kamaci BostanciNilgun Selcuk Duru
Apr 24, 2013·International Journal of Obesity : Journal of the International Association for the Study of Obesity·B LeonR O Cannon
Nov 20, 2012·European Heart Journal Cardiovascular Imaging·Fabien LabombardaEric Saloux
May 24, 2006·Heart·E IngelssonJ Sundström
Jul 11, 2006·International Heart Journal·H Asuman KaftanMustafa Kilic
Sep 14, 2011·Journal of Clinical Research in Pediatric Endocrinology·Mehmet Emre AtabekDerya Çimen
Dec 20, 2011·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Köksal CeyhanOrhan Onalan
Oct 13, 2014·JACC. Cardiovascular Imaging·Norman MangnerSandra Erbs
Jan 30, 2007·International Journal of Cardiology·Giuseppe MulèGiovanni Cerasola
May 25, 2005·Journal of Internal Medicine·G MulèG Cerasola
Sep 13, 2008·Cardiovascular Therapeutics·Aaron K F WongChim C Lang
Mar 20, 2013·Geriatrics & Gerontology International·Giorgio BasileAntonino Lasco
Apr 20, 2010·Cardiovascular Therapeutics·Wei YuWei Wang
Oct 29, 2009·Orvosi hetilap·András Nagy, Zsuzsanna Cserép
Sep 20, 2005·Journal of the American College of Cardiology·Sharon Ann HuntUNKNOWN American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evalua
Aug 10, 2010·Arquivos brasileiros de endocrinologia e metabologia·Arnaldo SchainbergJosé Marcio Ribeiro
Jan 14, 2004·Critical Care Nursing Clinics of North America·Pamela T RudisillSara Paul
Feb 14, 2014·Journal of Cardiovascular Medicine·Giuseppina NovoSalvatore Novo
Mar 7, 2007·Circulation·C HeldUNKNOWN ONTARGET/TRANSCEND Investigators
Apr 18, 2017·Journal of the American Veterinary Medical Association·Natalie HeliczerCristobal Navas de Solis
May 11, 2010·Fetal and Pediatric Pathology·Ali BulbulAli Ihsan Dokucu
Mar 20, 2019·Journal of Diabetes and Its Complications·Michael P BancksNorrina B Allen

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