PMID: 8610539Oct 1, 1995Paper

The effects of hyperosmolar agents lithium chloride and sucrose on the brain concentration of diminazene aceturate in rats

Acta Tropica
I E OdikaS M Anika

Abstract

The concentrations of diminazene aceturate in the brain of Trypanosoma brucei brucei infected and uninfected rats treated with diminazene aceturate (3.1 mg/kg, im) and either LiCl (2.5, 5.0 and 10 micrograms/kg) or sucrose (0.25, 0.5 and 1.0 g/kg) were determined. When diminazene aceturate was administered at a standard dose of 3.1 mg/kg (im), the addition of LiCl (10 micrograms/kg, im) increased significantly (P < 0.05) the concentration of the drug in the brains of both trypanosome infected and normal infected rats. The addition of sucrose (1.0 g/kg, im) instead of LiCl failed to give any significant increase in diminazene aceturate levels in the brain. The diminazene aceturate levels were significantly (P < 0.05) higher in the organs (brain, kidney, liver and spleen) of trypanosome infected compared to uninfected rats. The concentration of diminazene aceturate in the organs increased significantly (P < 0.05) with increasing concentrations of LiCl.

Citations

Mar 7, 2001·Veterinary Parasitology·B M AneneY Nawa
May 4, 1999·Memórias do Instituto Oswaldo Cruz·S L Croft
Mar 10, 2021·Drug and Chemical Toxicology·George Laylson da Silva Oliveira, Ana Paula Dos Santos C L da Silva
May 4, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Carsten OlbrichRainer H Müller

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