The effects of hypertension and body mass index on cognition in schizophrenia

The American Journal of Psychiatry
Joseph I FriedmanKenneth L Davis

Abstract

In recent years there has been a greater appreciation of the elevated prevalence of cardiovascular risk factors in the schizophrenia population and the liability some treatments have for their development. These vascular risk factors are in turn important risk factors in the development of dementia and more subtle cognitive impairments. However, their impact on the cognitive functions of patients with schizophrenia remains underexplored. The authors investigated whether vascular risk factors influence the cognitive impairments of schizophrenia and whether their effects on cognition in schizophrenia are different from those observed in nonpsychiatric comparison subjects. The authors compared 100 patients with schizophrenia and 53 comparison subjects on cognitive test performance in 2×2 matrices composed of individual vascular risk factors and group (schizophrenia patients and comparison subjects). Hypertension exerted a significant negative effect on immediate delayed and recognition memory in both groups. Patients with schizophrenia and hypertension were adversely affected in recognition memory, whereas comparison subjects were not. A body mass index above 25 was associated with negative effects on delayed memory in both groups...Continue Reading

Citations

Jan 12, 2011·Journal of Affective Disorders·Roger S McIntyre
Oct 15, 2013·Schizophrenia Research·Nur Amirah Abdul RashidJimmy Lee
Aug 29, 2012·Cardiology Research and Practice·Barbara RiegelStephen T Moelter
Jul 30, 2014·Psychological Medicine·E Bora
Dec 15, 2012·The Mount Sinai Journal of Medicine, New York·Cheuk Ying TangJoseph I Friedman
Dec 18, 2014·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Rumiko KawanoHeii Arai
Oct 22, 2016·Current Behavioral Neuroscience Reports·Julia VakhrushevaDavid Kimhy
Oct 4, 2012·Schizophrenia Research·Yoichiro TakayanagiWilliam W Eaton
Jun 7, 2011·Schizophrenia Research·Cheuk Ying TangKenneth L Davis
Jun 13, 2015·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·N LacknerE Z Reininghaus
Jun 1, 2015·Journal of Psychiatric Research·Kayla M WheartyGregory P Strauss
Sep 26, 2014·Schizophrenia Research. Cognition·M StrassnigP D Harvey
Mar 3, 2015·Schizophrenia Research·Tyler GroveVicki Ellingrod
Oct 31, 2012·Schizophrenia Research·Jean Pierre LindenmayerDeborah Wance
May 9, 2015·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Ali S GoughariNouzar Nakhaee
Mar 23, 2013·Clinical Schizophrenia & Related Psychoses·Brian KirkpatrickEmilio Fernandez-Egea
Aug 14, 2019·Biomolecules·Bahare SalehiJavad Sharifi-Rad
May 20, 2020·Frontiers in Psychiatry·Katarzyna AdamowiczJolanta Kucharska-Mazur
Mar 12, 2021·Frontiers in Human Neuroscience·Xing-Jie PengRen-Rong Wu

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