The effects of hypoglycaemia on cerebral blood flow and metabolism in the new-born calf

The Journal of Physiology
R M Gardiner

Abstract

1. The effects of insulin hypoglycaemia on cerebral blood flow and metabolism have been examined in unanaesthetized, unrestrained calves between 1 and 26 days after birth. 2. Cerebral blood flow was measured with an inert gas technique using molecular hydrogen, and cerebral metabolism was quantified by determination of arterio-cerebral venous (A--V) concentration differences for oxygen, glucose, lactate, pyruvate, acetoacetate, beta-D-hydroxybutyrate and ammonia. 3. During normoglycaemia the mean (A--V) difference for glucose was close to one sixth that of oxygen, on a molar basis. A small net loss of pyruvate from the brain was found, but there was no significant (A--V) difference for lactate. Arterial concentrations of acetoacetate and beta-D-hydroxybutyrate were low, and no utilization of ketone bodies by the brain was demonstrated. 4. Moderate hypoglycaemia (arterial plasma glucose concentration 1--2 m-mole/l.) had no measurable effect on either cerebral blood flow or metabolism. 5. During profound hypoglycaemia (arterial plasma glucose concentration less than 1.0 m-mole/l.) cerebral glucose uptake was sufficient to account for only 56% of the cerebral oxygen consumption. Cerebral oxygen consumption fell in comatose animals...Continue Reading

Citations

Jul 1, 1993·Baillière's Clinical Endocrinology and Metabolism·R N Auer, B K Siesjö
Jul 1, 1993·Baillière's Clinical Endocrinology and Metabolism·A Nehlig
Feb 1, 1993·Progress in Neurobiology·A Nehlig, A Pereira de Vasconcelos
May 1, 1984·Brain Research·A L MillerD M Staton
Feb 24, 2007·Neurochemistry International·Cecilie MorlandBjørnar Hassel
Jun 20, 2012·The European Journal of Neuroscience·Kevin E ChapmanAmy Brooks-Kayal
Dec 1, 1983·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·B K SiesjöD Pelligrino
Feb 1, 1987·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R M BryanR B Page
Jun 1, 1986·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R M Bryan, F F Jöbsis
Dec 1, 1982·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M KatoY Kuroiwa
Mar 15, 2006·Biology of the Neonate·Paul J Rozance, William W Hay
Oct 1, 1992·Stroke; a Journal of Cerebral Circulation·A R LaptookJ Ruley
May 1, 1995·Acta Paediatrica·H LethO Henriksen
Mar 1, 1988·Diabetes/metabolism Reviews·B K Siesjö
Dec 1, 1982·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J E Cremer

Related Concepts

Ammonia
Metazoa
Blood Glucose
Brain
Bos indicus
Cerebrovascular Circulation
Anhydrous Dextrose
Reactive Hypoglycemia
Insulin B Chain
Lactates

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