The effects of IL-10 gene polymorphism on serum, and gingival crevicular fluid levels of IL-6 and IL-10 in chronic periodontitis

Journal of Applied Oral Science : Revista FOB
Hulya TokerOmer Poyraz

Abstract

Anti-inflammatory cytokines play a crucial role in periodontitis by inhibiting synthesis of pro-inflammatory cytokines. The purpose of this study was to evaluate the effect of interleukin-10 (-597) gene polymorphism and genotype distributions on chronic periodontitis (CP) development and IL-6 and IL-10 levels in gingival crevicular fluid (GCF) and serum before and after non-surgical periodontal treatment. The study population consisted of 55 severe generalized CP patients as CP group and 50 healthy individuals as control group. Plaque index, gingival index, probing depth and clinical attachment level were recorded and GCF and blood samples were taken at both the baseline and the sixth week after non-surgical periodontal treatment. PCR-RFLP procedure was used for gene analyses and cytokine levels were measured via ELISA. IL-10 genotype distribution was significantly different between CP and control groups (p=0.000, OR:7, 95%CI, 2.83-60.25). Clinical measurements significantly improved in the CP group after periodontal treatment (p<0.05). Periodontal treatment significantly decreased GCF IL-6 and IL-10 levels. No significant difference was found in clinical parameters between IL-10 AA and AC+CC genotypes at both the baseline and ...Continue Reading

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Citations

Apr 6, 2019·Frontiers in Physiology·Railson de Oliveira FerreiraRafael Rodrigues Lima
Dec 18, 2020·Journal of Clinical Medicine·Małgorzata KozakAndrzej Pawlik
Nov 5, 2020·Cytokine·Nidhi MedaraNeil M O'Brien-Simpson
Mar 9, 2019·Life Sciences·Maria Karolina Martins FerreiraRafael Rodrigues Lima

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Methods Mentioned

BETA
genotyping
ELISA
PCR
electrophoresis

Software Mentioned

SPSS

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