PMID: 1190907Sep 1, 1975Paper

[The effects of imolamine on auriculo-ventricular conduction by recoil of His potential].

Archives Internationales De Pharmacodynamie Et De Thérapie
J Junien, C Lakatos

Abstract

The electropharmacological action of imolamine was studied using Hiss bundle electrography. In dogs with spontaneous sinusal rhythm, imolamine decreases Hiss-Purkinje and total intraventricular conduction, without affecting auriculoventricular conduction time. In dogs with paced sinusal rhythm (180/min), imolamine increases atrial and ventricular thresholds and atrial refractory period, and decreases intra-atrial and intraventricular conduction; no significant modification of auriculoventricular conduction was noted at therapeutic dosages. In ouabaïn-intoxicated dogs, imolamine suppresses digitalis rhythm disorders and antagonizes the action of the glycoside on A-V node, as does diphenylhydantoïne, but, in contrast to this drug, it increases slightly intraventricular conductivity.

Related Concepts

Related Feeds

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.