The effects of in utero bisphenol A exposure on reproductive capacity in several generations of mice

Toxicology and Applied Pharmacology
Ayelet Ziv-GalJodi A Flaws

Abstract

In utero bisphenol A (BPA) exposure affects reproductive function in the first generation (F1) of mice; however, not many studies have examined the reproductive effects of BPA exposure on subsequent generations. In this study, pregnant mice (F0) were orally dosed with vehicle, BPA (0.5, 20, and 50 μg/kg/day) or diethylstilbestrol (DES; 0.05 μg/kg/day) daily from gestation day 11 until birth. F1 females were used to generate the F2 generation, and F2 females were used to generate the F3 generation. Breeding studies at the ages of 3, 6, and 9 months were conducted to evaluate reproductive capacity over time. Further, studies were conducted to evaluate pubertal onset, litter size, and percentage of dead pups; and to calculate pregnancy rate, and mating, fertility, and gestational indices. The results indicate that BPA exposure (0.5 and 50 μg/kg/day) significantly delayed the age at vaginal opening in the F3 generation compared to vehicle control. Both DES (0.05 μg/kg/day) and BPA (50 μg/kg/day) significantly delayed the age at first estrus in the F3 generation compared to vehicle control. BPA exposure reduced gestational index in the F1 and F2 generations compared to control. Further, BPA exposure (0.5 μg/kg/day) compromised the f...Continue Reading

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Citations

Jan 10, 2016·Reproductive Toxicology·Amelia BergerJodi A Flaws
Jan 9, 2016·Critical Reviews in Food Science and Nutrition·Ilaria PaterniFilippo Minutolo
Sep 25, 2015·BMC Medical Research Methodology·Joseph B StanfordUNKNOWN U.S. National Children’s Study
Jul 16, 2016·Fertility and Sterility·Ayelet Ziv-Gal, Jodi A Flaws
Jun 14, 2017·Journal of Applied Toxicology : JAT·Agnieszka Tomza-MarciniakBogumiła Pilarczyk
Feb 23, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Saniya RattanJodi A Flaws
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Jan 11, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Mingxin ShiKanako Hayashi
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May 12, 2019·Biology of Reproduction·Saniya Rattan, Jodi A Flaws
May 28, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Mingxin ShiKanako Hayashi
Aug 30, 2018·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Karin DietrichMarianne Mathäs
Mar 3, 2020·Photochemistry and Photobiology·Olga V VorobyevaVladimir I Yusupov
Oct 20, 2018·Nature Reviews. Endocrinology·Genoa R Warner, Jodi A Flaws
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