PMID: 8582082Oct 1, 1995Paper

The effects of in vitro cotitine on nasal ciliary beat frequency

Clinical Otolaryngology and Allied Sciences
A M AgiusA Smallman

Abstract

Cotitine is one of the main metabolites of nicotine. It is stable and in vivo has a relatively long circulating half life. Nasal ciliated cells from non-smoking individuals were exposed in vitro to solutions of cotitine corresponding to serum levels in active and passive smokers. Ciliary beat frequency was measured by a computerized photometric technique. There was a significant drop in ciliary beat frequency compared with control ciliated cells in phosphate buffered saline. It is concluded that cotitine in active or passive smoking has a marked effect on ciliary function. It may be a factor leading to diminished mucociliary clearance and persistent middle ear effusion.

References

Apr 1, 1992·Clinical Otolaryngology and Allied Sciences·A M RobsonA B Drake-Lee
Jul 1, 1992·International Journal of Pediatric Otorhinolaryngology·J M Rowe-Jones, M J Brockbank
Oct 1, 1992·The Annals of Otology, Rhinology, and Laryngology·H Takahashi, I Sando
Oct 1, 1992·Clinical Otolaryngology and Allied Sciences·A R MawM G Dilkes
Jan 1, 1991·Journal of Clinical Epidemiology·M WoodwardR Tavendale
Jan 1, 1991·Journal of Clinical Epidemiology·H Tunstall-PedoeC A Brown
Jun 10, 1989·BMJ : British Medical Journal·D P StrachanC Feyerabend
Jun 1, 1989·The Journal of Laryngology and Otology·A E Hinton
Dec 1, 1986·The Journal of Pharmacy and Pharmacology·C FeyerabendM A Russell
Nov 1, 1988·The Journal of Laryngology and Otology·A E Hinton, G Buckley
Jun 1, 1972·Archives of Otolaryngology·M Tos, K Bak-Pedersen
Jan 1, 1974·Respiration; International Review of Thoracic Diseases·J Iravani, G N Melville
Aug 1, 1967·Archives of Otolaryngology·J Sadé
Oct 1, 1983·Archives of Otolaryngology·J NuutinenP Karjalainen
Dec 1, 1984·Journal of Epidemiology and Community Health·M JarvisY Salloojee
Dec 1, 1982·Clinical Otolaryngology and Allied Sciences·M Pedersen, N Mygind
Dec 1, 1982·Clinical Pharmacology and Therapeutics·G A KyerematenE S Vesell
Jan 1, 1995·Acta Oto-laryngologica·A M AgiusL A Smallman
Dec 1, 1994·The Journal of Laryngology and Otology·A M AgiusL A Smallman
Apr 1, 1994·Clinical Otolaryngology and Allied Sciences·A R Maw, R Bawden
Mar 1, 1993·Journal of Medical Engineering & Technology·A GreenA B Drake-Lee

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Citations

Dec 31, 1997·Mutation Research·C J Reed
Nov 14, 2006·Otolaryngologic Clinics of North America·John W Seibert, Christopher J Danner
Nov 16, 2016·Cells·Asma Yaghi, Myrna B Dolovich
Aug 16, 2000·Clinical Otolaryngology and Allied Sciences·H KubbaJ P Birchall
Dec 17, 2014·American Journal of Rhinology & Allergy·Alan D Workman, Noam A Cohen
Apr 30, 2009·American Journal of Rhinology & Allergy·Edwin TamashiroNoam A Cohen
Aug 9, 2011·American Journal of Rhinology & Allergy·Sujata DeAndrew S Jones

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