The effects of increased intracortical remodeling on microcrack behaviour in compact bone

Bone
Oran D KennedyT Clive Lee

Abstract

The behaviour of microdamage in bone is related to its microstructural features and thus has an important role in tissue structural properties. However, it is not known how cracks behave in areas of increased intracortical remodeling. More remodeling creates wider variation in the properties of the primary microstructural features of cortical bone, namely osteons. This situation may occur after treatment involving parathyroid hormone or events such as menopause/ovariectomy. High turnover was modeled in this study by using ovariectomy (OVX) to induce surgical menopause in sheep. We hypothesized that osteon age would influence microcrack behaviour during propagation. Five fluorochrome dyes were administered intravenously at different time-points over 12 months post-OVX to label remodeling sites and all animals were then euthanized. Compact bone specimens (2x2x36 mm) were harvested from the right metatarsal. Samples were cyclically loaded to failure and then histological analyses were carried out. Cracks were categorized by length into three groups; short (<100 mum), intermediate (100-300 mum) and long (>300 mum). Numerical crack density (Cr.Dn) of long cracks was greater in controls compared with OVX. Controls also displayed a hi...Continue Reading

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Citations

Jan 25, 2012·Calcified Tissue International·Monika RumplerKlaus Klaushofer
Aug 28, 2013·Calcified Tissue International·L M HavillD P Nicolella
Jan 22, 2011·Biomechanics and Modeling in Mechanobiology·Vu-Hieu NguyenSalah Naili
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