The effects of indomethacin in treated hypertensive patients

Clinical and Experimental Pharmacology & Physiology
L M WingM J West

Abstract

1. Twelve treated hypertensive patients (ages 58-71 years) who had also been treated for joint disease participated in a randomized double-blind crossover placebo-controlled study to investigate the effects of indomethacin (25 mg three times daily) on blood pressure and biochemical parameters over a 6-week period. 2. Blood pressure was increased in all patients throughout the indomethacin treatment period (P less than 0.001)--average mean blood pressure increases were 9 mmHg (casual), 8 mmHg (supine), 10 mmHg (standing). 3. The blood pressure increase during indomethacin treatment was independent of the particular antihypertensive regimen in use. 4. Plasma aldosterone concentration was reduced by 50% (P less than 0.01), plasma renin activity was reduced by 43% (P = 0.102) and plasma urea concentration was increased by 17% (P less than 0.001) during indomethacin treatment. 5. The findings confirm that indomethacin impairs the blood pressure lowering effect of antihypertensive regimens.

References

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Citations

Jan 1, 1987·European Journal of Clinical Pharmacology·P P KoopmansF W Gribnau
Jan 1, 1987·Pharmacology & Therapeutics·R O DayJ de Jager
Jan 1, 1987·Clinical and Experimental Hypertension. Part A, Theory and Practice·A SalvettiR Pedrinelli
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Apr 1, 1985·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M C Smith, M J Dunn
Aug 1, 1986·Australian and New Zealand Journal of Medicine·A DavisE J Begg
Jun 1, 1989·Journal of Clinical Pharmacology·A A SchunaT L Goodfriend

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